Vhf09726 details

Gene vhfRNAi AccessionVhf09726
Gene SymbolNALCN
Gene DescriptionSodium leak channel non-selective protein (CanIon) (Voltage gated channel-like protein 1)
Gene Name in PaperNALCN
GroupHost Factor
Ensembl Gene IDENST00000251127 ENST00000376200 
UniProt IDQ8IZF0
Entrez Gene ID259232
GOView
Host OrganismHomo sapiens
Virus Virus full namePoliovirus
Virus AbbreviationPV
TaxonomyView
Results PhenotypeIncreased infection
Hits Number*124
Confirmed Hits Number27 
ScoreNA
UnitNA
Methods Assay Type Cell-based
BioModel DescriptionHEp-2C and Vero cells
Confirmatory Screen DescriptionELISA
Primary Screen Description#Z-score of ≥ 3.0
Note/CommentA collection of host virus resistance genes that was identified upon silencing increased poliovirus and enterovirus 71 production
References Pubmed ID26581994
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*Replicates that are beyond 2-3 standard deviation values from the mean (Sharma 2009)
#A strong signal/background ratio with low variation in the assay (Zhang 1999)