Vhf08721 details

Gene vhfRNAi AccessionVhf08721
Gene SymbolPHAR3
Gene DescriptionPhosphatase and actin regulator 3 (Scaffold-associated PP1-inhibiting protein) (Scapinin)
Gene Name in PaperPHAR3
GroupHost Factor
Ensembl Gene IDENST00000355648 ENST00000359926 ENST00000361300 ENST00000371015 ENST00000395636 ENST00000541461 
UniProt IDQ96KR7
Entrez Gene ID116154
GOView
Host OrganismHomo sapiens
Virus Virus full namePoliovirus
Virus AbbreviationPV
TaxonomyView
Results PhenotypeIncreased infection
Hits Number*124
Confirmed Hits Number27 
ScoreNA
UnitNA
Methods Assay Type Cell-based
BioModel DescriptionHEp-2C and Vero cells
Confirmatory Screen DescriptionELISA
Primary Screen Description#Z-score of ≥ 3.0
Note/CommentA collection of host virus resistance genes that was identified upon silencing increased poliovirus and enterovirus 71 production
References Pubmed ID26581994
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*Replicates that are beyond 2-3 standard deviation values from the mean (Sharma 2009)
#A strong signal/background ratio with low variation in the assay (Zhang 1999)