Vhf08642 details

Gene vhfRNAi AccessionVhf08642
Gene SymbolGRM1
Gene DescriptionMetabotropic glutamate receptor 1 (mGluR1)
Gene Name in PaperGRM1
GroupHost Factor
Ensembl Gene IDENST00000282753 ENST00000355289 ENST00000361719 ENST00000492807 ENST00000507907 
UniProt IDQ13255
Entrez Gene ID2911
GOView
Host OrganismHomo sapiens
Virus Virus full namePoliovirus
Virus AbbreviationPV
TaxonomyView
Results PhenotypeIncreased infection
Hits Number*124
Confirmed Hits Number27 
ScoreNA
UnitNA
Methods Assay Type Cell-based
BioModel DescriptionHEp-2C and Vero cells
Confirmatory Screen DescriptionELISA
Primary Screen Description#Z-score of ≥ 3.0
Note/CommentA collection of host virus resistance genes that was identified upon silencing increased poliovirus and enterovirus 71 production
References Pubmed ID26581994
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*Replicates that are beyond 2-3 standard deviation values from the mean (Sharma 2009)
#A strong signal/background ratio with low variation in the assay (Zhang 1999)