Vhf08166 details

Gene vhfRNAi AccessionVhf08166
Gene SymbolPHLB2
Gene DescriptionPleckstrin homology-like domain family B member 2 (Protein LL5-beta)
Gene Name in PaperPHLB2
GroupHost Factor
Ensembl Gene IDENST00000393923 ENST00000393925 ENST00000412622 ENST00000431670 ENST00000481953 
UniProt IDQ86SQ0
Entrez Gene ID90102
GOView
Host OrganismHomo sapiens
Virus Virus full namePoliovirus
Virus AbbreviationPV
TaxonomyView
Results PhenotypeIncreased infection
Hits Number*124
Confirmed Hits Number27 
ScoreNA
UnitNA
Methods Assay Type Cell-based
BioModel DescriptionHEp-2C and Vero cells
Confirmatory Screen DescriptionELISA
Primary Screen Description#Z-score of ≥ 3.0
Note/CommentA collection of host virus resistance genes that was identified upon silencing increased poliovirus and enterovirus 71 production
References Pubmed ID26581994
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*Replicates that are beyond 2-3 standard deviation values from the mean (Sharma 2009)
#A strong signal/background ratio with low variation in the assay (Zhang 1999)