RNAi screen analysis of viral host genes
| Gene | vhfRNAi Accession | Vhf08023 |
| Gene Symbol | OPTN | |
| Gene Description | Optineurin (E3-14.7K-interacting protein) (FIP-2) (Huntingtin yeast partner L) (Huntingtin-interacting protein 7) (HIP-7) (Huntingtin-interacting protein L) (NEMO-related protein) (Optic neuropathy-inducing protein) (Transcription factor IIIA-interacting protein) (TFIIIA-IntP) | |
| Gene Name in Paper | OPTN | |
| Group | Host Factor | |
| Ensembl Gene ID | ENST00000263036 ENST00000378747 ENST00000378748 ENST00000378752 ENST00000378757 ENST00000378764 | |
| UniProt ID | Q96CV9 | |
| Entrez Gene ID | 10133 | |
| GO | View | |
| Host | Organism | Homo sapiens |
| Virus | Virus full name | Poliovirus |
| Virus Abbreviation | PV | |
| Taxonomy | View | |
| Results | Phenotype | Increased infection |
| Hits Number* | 124 | |
| Confirmed Hits Number | 27 | |
| Score | NA | |
| Unit | NA | |
| Methods | Assay Type | Cell-based |
| BioModel Description | HEp-2C and Vero cells | |
| Confirmatory Screen Description | ELISA | |
| Primary Screen Description# | Z-score of ≥ 3.0 | |
| Note/Comment | A collection of host virus resistance genes that was identified upon silencing increased poliovirus and enterovirus 71 production | |
| References | Pubmed ID | 26581994 |