RNAi screen analysis of viral host genes
| Gene | vhfRNAi Accession | Vhf07919 |
| Gene Symbol | TNFA | |
| Gene Description | Tumor necrosis factor (Cachectin) (TNF-alpha) (Tumor necrosis factor ligand superfamily member 2) (TNF-a) [Cleaved into: Tumor necrosis factor, membrane form (N-terminal fragment) (NTF); Intracellular domain 1 (ICD1); Intracellular domain 2 (ICD2); C-domain 1; C-domain 2; Tumor necrosis factor, soluble form] | |
| Gene Name in Paper | TNFA | |
| Group | Host Factor | |
| Ensembl Gene ID | ENST00000376122 ENST00000383496 ENST00000412275 ENST00000420425 ENST00000443707 ENST00000448781 ENST00000449264 | |
| UniProt ID | P01375 | |
| Entrez Gene ID | 7124 | |
| GO | View | |
| Host | Organism | Homo sapiens |
| Virus | Virus full name | Poliovirus |
| Virus Abbreviation | PV | |
| Taxonomy | View | |
| Results | Phenotype | Increased infection |
| Hits Number* | 124 | |
| Confirmed Hits Number | 27 | |
| Score | NA | |
| Unit | NA | |
| Methods | Assay Type | Cell-based |
| BioModel Description | HEp-2C and Vero cells | |
| Confirmatory Screen Description | ELISA | |
| Primary Screen Description# | Z-score of ≥ 3.0 | |
| Note/Comment | A collection of host virus resistance genes that was identified upon silencing increased poliovirus and enterovirus 71 production | |
| References | Pubmed ID | 26581994 |