RNAi screen analysis of viral host genes
| Gene | vhfRNAi Accession | Vhf07879 |
| Gene Symbol | CD59 | |
| Gene Description | CD59 glycoprotein (1F5 antigen) (20 kDa homologous restriction factor) (HRF-20) (HRF20) (MAC-inhibitory protein) (MAC-IP) (MEM43 antigen) (Membrane attack complex inhibition factor) (MACIF) (Membrane inhibitor of reactive lysis) (MIRL) (Protectin) (CD antigen CD59) | |
| Gene Name in Paper | CD59 | |
| Group | Host Factor | |
| Ensembl Gene ID | ENST00000351554 ENST00000395850 ENST00000415002 ENST00000426650 ENST00000437761 ENST00000445143 ENST00000525763 ENST00000527577 ENST00000528700 | |
| UniProt ID | P13987 | |
| Entrez Gene ID | 966 | |
| GO | View | |
| Host | Organism | Homo sapiens |
| Virus | Virus full name | Poliovirus |
| Virus Abbreviation | PV | |
| Taxonomy | View | |
| Results | Phenotype | Increased infection |
| Hits Number* | 124 | |
| Confirmed Hits Number | 27 | |
| Score | NA | |
| Unit | NA | |
| Methods | Assay Type | Cell-based |
| BioModel Description | HEp-2C and Vero cells | |
| Confirmatory Screen Description | ELISA | |
| Primary Screen Description# | Z-score of ≥ 3.0 | |
| Note/Comment | A collection of host virus resistance genes that was identified upon silencing increased poliovirus and enterovirus 71 production | |
| References | Pubmed ID | 26581994 |