RNAi screen analysis of viral host genes
| Gene | vhfRNAi Accession | Vhf07838 |
| Gene Symbol | PLCH1 | |
| Gene Description | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 (EC 3.1.4.11) (Phosphoinositide phospholipase C-eta-1) (Phospholipase C-eta-1) (PLC-eta-1) (Phospholipase C-like protein 3) (PLC-L3) | |
| Gene Name in Paper | PLCH1 | |
| Group | Host Factor | |
| Ensembl Gene ID | ENST00000334686 ENST00000340059 ENST00000447496 ENST00000460012 ENST00000494598 | |
| UniProt ID | Q4KWH8 | |
| Entrez Gene ID | 23007 | |
| GO | View | |
| Host | Organism | Homo sapiens |
| Virus | Virus full name | Poliovirus |
| Virus Abbreviation | PV | |
| Taxonomy | View | |
| Results | Phenotype | Increased infection |
| Hits Number* | 124 | |
| Confirmed Hits Number | 27 | |
| Score | NA | |
| Unit | NA | |
| Methods | Assay Type | Cell-based |
| BioModel Description | HEp-2C and Vero cells | |
| Confirmatory Screen Description | ELISA | |
| Primary Screen Description# | Z-score of ≥ 3.0 | |
| Note/Comment | A collection of host virus resistance genes that was identified upon silencing increased poliovirus and enterovirus 71 production | |
| References | Pubmed ID | 26581994 |