RNAi screen analysis of viral host genes
| Gene | vhfRNAi Accession | Vhf07085 |
| Gene Symbol | RFFL | |
| Gene Description | E3 ubiquitin-protein ligase rififylin (EC 6.3.2.-) (Caspase regulator CARP2) (Caspases-8 and -10-associated RING finger protein 2) (CARP-2) (FYVE-RING finger protein Sakura) (Fring) (RING finger and FYVE-like domain-containing protein 1) (RING finger protein 189) (RING finger protein 34-like) | |
| Gene Name in Paper | RFFL | |
| Group | Host Factor | |
| Ensembl Gene ID | ENST00000315249 ENST00000394597 ENST00000413582 ENST00000415395 ENST00000447669 ENST00000584655 | |
| UniProt ID | Q8WZ73 | |
| Entrez Gene ID | 117584 | |
| GO | View | |
| Host | Organism | Homo sapiens |
| Virus | Virus full name | Poliovirus |
| Virus Abbreviation | PV | |
| Taxonomy | View | |
| Results | Phenotype | Increased infection |
| Hits Number* | 124 | |
| Confirmed Hits Number | 27 | |
| Score | NA | |
| Unit | NA | |
| Methods | Assay Type | Cell-based |
| BioModel Description | HEp-2C and Vero cells | |
| Confirmatory Screen Description | ELISA | |
| Primary Screen Description# | Z-score of ≥ 3.0 | |
| Note/Comment | A collection of host virus resistance genes that was identified upon silencing increased poliovirus and enterovirus 71 production | |
| References | Pubmed ID | 26581994 |