Vhf06959 details

Gene vhfRNAi AccessionVhf06959
Gene SymbolUPP1
Gene DescriptionUridine phosphorylase 1 (UPase 1) (UrdPase 1) (EC 2.4.2.3)
Gene Name in PaperUPP1
GroupHost Factor
Ensembl Gene IDENST00000331803 ENST00000395560 ENST00000395564 ENST00000417464 ENST00000457596 
UniProt IDQ16831
Entrez Gene ID7378
GOView
Host OrganismHomo sapiens
Virus Virus full namePoliovirus
Virus AbbreviationPV
TaxonomyView
Results PhenotypeIncreased infection
Hits Number*124
Confirmed Hits Number27 
ScoreNA
UnitNA
Methods Assay Type Cell-based
BioModel DescriptionHEp-2C and Vero cells
Confirmatory Screen DescriptionELISA
Primary Screen Description#Z-score of ≥ 3.0
Note/CommentA collection of host virus resistance genes that was identified upon silencing increased poliovirus and enterovirus 71 production
References Pubmed ID26581994
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*Replicates that are beyond 2-3 standard deviation values from the mean (Sharma 2009)
#A strong signal/background ratio with low variation in the assay (Zhang 1999)