Vhf06841 details

Gene vhfRNAi AccessionVhf06841
Gene SymbolGARE1
Gene DescriptionGRB2-associated and regulator of MAPK protein 1 (GRB2-associated and regulator of MAPK1)
Gene Name in PaperGARE1
GroupHost Factor
Ensembl Gene IDENST00000269209 ENST00000399218 
UniProt IDQ9H706
Entrez Gene ID64762
GOView
Host OrganismHomo sapiens
Virus Virus full namePoliovirus
Virus AbbreviationPV
TaxonomyView
Results PhenotypeIncreased infection
Hits Number*124
Confirmed Hits Number27 
ScoreNA
UnitNA
Methods Assay Type Cell-based
BioModel DescriptionHEp-2C and Vero cells
Confirmatory Screen DescriptionELISA
Primary Screen Description#Z-score of ≥ 3.0
Note/CommentA collection of host virus resistance genes that was identified upon silencing increased poliovirus and enterovirus 71 production
References Pubmed ID26581994
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*Replicates that are beyond 2-3 standard deviation values from the mean (Sharma 2009)
#A strong signal/background ratio with low variation in the assay (Zhang 1999)