RNAi screen analysis of viral host genes
| Gene | vhfRNAi Accession | Vhf06750 |
| Gene Symbol | SIAT6 | |
| Gene Description | CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase (EC 2.4.99.6) (Beta-galactoside alpha-2,3-sialyltransferase 3) (Alpha 2,3-ST 3) (Gal beta-1,3(4) GlcNAc alpha-2,3 sialyltransferase) (N-acetyllactosaminide alpha-2,3-sialyltransferase) (ST3Gal III) (ST3GalIII) (ST3N) (Sialyltransferase 6) | |
| Gene Name in Paper | SIAT6 | |
| Group | Host Factor | |
| Ensembl Gene ID | ENST00000262915 ENST00000330208 ENST00000332628 ENST00000335430 ENST00000347631 ENST00000351035 ENST00000353126 ENST00000361392 ENST00000361400 ENST00000361746 ENST00000361812 ENST00000372362 ENST00000372365 ENST00000372366 ENST00000372367 ENST00000372368 ENST00000372369 ENST00000372372 ENST00000372374 ENST00000469715 ENST00000489897 ENST00000490541 ENST00000528371 ENST00000530581 ENST00000531451 ENST00000531816 ENST00000531993 ENST00000533212 ENST00000533933 ENST00000533997 ENST00000545417 | |
| UniProt ID | Q11203 | |
| Entrez Gene ID | 6487 | |
| GO | View | |
| Host | Organism | Homo sapiens |
| Virus | Virus full name | Poliovirus |
| Virus Abbreviation | PV | |
| Taxonomy | View | |
| Results | Phenotype | Increased infection |
| Hits Number* | 124 | |
| Confirmed Hits Number | 27 | |
| Score | NA | |
| Unit | NA | |
| Methods | Assay Type | Cell-based |
| BioModel Description | HEp-2C and Vero cells | |
| Confirmatory Screen Description | ELISA | |
| Primary Screen Description# | Z-score of ≥ 3.0 | |
| Note/Comment | A collection of host virus resistance genes that was identified upon silencing increased poliovirus and enterovirus 71 production | |
| References | Pubmed ID | 26581994 |