Vhf06630 details

Gene vhfRNAi AccessionVhf06630
Gene SymbolTRPM2
Gene DescriptionTransient receptor potential cation channel subfamily M member 2 (EC 3.6.1.13) (Estrogen-responsive element-associated gene 1 protein) (Long transient receptor potential channel 2) (LTrpC-2) (LTrpC2) (Transient receptor potential channel 7) (TrpC7)
Gene Name in PaperTRPM2
GroupHost Factor
Ensembl Gene IDENST00000300481 ENST00000300482 ENST00000397928 
UniProt IDO94759
Entrez Gene ID7226
GOView
Host OrganismHomo sapiens
Virus Virus full namePoliovirus
Virus AbbreviationPV
TaxonomyView
Results PhenotypeIncreased infection
Hits Number*124
Confirmed Hits Number27 
ScoreNA
UnitNA
Methods Assay Type Cell-based
BioModel DescriptionHEp-2C and Vero cells
Confirmatory Screen DescriptionELISA
Primary Screen Description#Z-score of ≥ 3.0
Note/CommentA collection of host virus resistance genes that was identified upon silencing increased poliovirus and enterovirus 71 production
References Pubmed ID26581994
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*Replicates that are beyond 2-3 standard deviation values from the mean (Sharma 2009)
#A strong signal/background ratio with low variation in the assay (Zhang 1999)