RNAi screen analysis of viral host genes
| Gene | vhfRNAi Accession | Vhf06050 |
| Gene Symbol | NPL | |
| Gene Description | N-acetylneuraminate lyase (NALase) (EC 4.1.3.3) (N-acetylneuraminate pyruvate-lyase) (N-acetylneuraminic acid aldolase) (Sialate lyase) (Sialate-pyruvate lyase) (Sialic acid aldolase) (Sialic acid lyase) | |
| Gene Name in Paper | NPL | |
| Group | Host Factor | |
| Ensembl Gene ID | ENST00000258317 ENST00000367552 ENST00000367553 ENST00000367554 ENST00000367555 | |
| UniProt ID | Q9BXD5 | |
| Entrez Gene ID | 80896 | |
| GO | View | |
| Host | Organism | Homo sapiens |
| Virus | Virus full name | Poliovirus |
| Virus Abbreviation | PV | |
| Taxonomy | View | |
| Results | Phenotype | Increased infection |
| Hits Number* | 124 | |
| Confirmed Hits Number | 27 | |
| Score | NA | |
| Unit | NA | |
| Methods | Assay Type | Cell-based |
| BioModel Description | HEp-2C and Vero cells | |
| Confirmatory Screen Description | ELISA | |
| Primary Screen Description# | Z-score of ≥ 3.0 | |
| Note/Comment | A collection of host virus resistance genes that was identified upon silencing increased poliovirus and enterovirus 71 production | |
| References | Pubmed ID | 26581994 |