RNAi screen analysis of viral host genes
| Gene | vhfRNAi Accession | Vhf05976 |
| Gene Symbol | MMEL1 | |
| Gene Description | Membrane metallo-endopeptidase-like 1 (EC 3.4.24.11) (Membrane metallo-endopeptidase-like 2) (NEP2(m)) (Neprilysin II) (NEPII) (Neprilysin-2) (NEP2) (NL2) [Cleaved into: Membrane metallo-endopeptidase-like 1, soluble form (Neprilysin-2 secreted) (NEP2(s))] | |
| Gene Name in Paper | MMEL1 | |
| Group | Host Factor | |
| Ensembl Gene ID | ENST00000378412 ENST00000502556 ENST00000504800 ENST00000611357 ENST00000621908 ENST00000628503 | |
| UniProt ID | Q495T6 | |
| Entrez Gene ID | 79258 | |
| GO | View | |
| Host | Organism | Homo sapiens |
| Virus | Virus full name | Poliovirus |
| Virus Abbreviation | PV | |
| Taxonomy | View | |
| Results | Phenotype | Increased infection |
| Hits Number* | 124 | |
| Confirmed Hits Number | 27 | |
| Score | NA | |
| Unit | NA | |
| Methods | Assay Type | Cell-based |
| BioModel Description | HEp-2C and Vero cells | |
| Confirmatory Screen Description | ELISA | |
| Primary Screen Description# | Z-score of ≥ 3.0 | |
| Note/Comment | A collection of host virus resistance genes that was identified upon silencing increased poliovirus and enterovirus 71 production | |
| References | Pubmed ID | 26581994 |