RNAi screen analysis of viral host genes
| Gene | vhfRNAi Accession | Vhf05847 |
| Gene Symbol | EXT1 | |
| Gene Description | Exostosin-1 (EC 2.4.1.224) (EC 2.4.1.225) (Glucuronosyl-N-acetylglucosaminyl-proteoglycan/N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase) (Multiple exostoses protein 1) (Putative tumor suppressor protein EXT1) | |
| Gene Name in Paper | EXT1 | |
| Group | Restriction Factor | |
| Ensembl Gene ID | ENST00000378204 | |
| UniProt ID | Q16394 | |
| Entrez Gene ID | 2131 | |
| GO | View | |
| Host | Organism | Homo sapiens |
| Virus | Virus full name | Marburgvirus |
| Virus Abbreviation | MARV | |
| Taxonomy | View | |
| Results | Phenotype | Inhibited infection |
| Hits Number* | 173 | |
| Confirmed Hits Number | 106 | |
| Score | ?0.07 | |
| Unit | z-score | |
| Methods | Assay Type | cell-based |
| BioModel Description | Human 293T embryonic kidney cells and human lung epithelial A549 cells | |
| Confirmatory Screen Description | Luciferase | |
| Primary Screen Description# | z-scores greater than 2 | |
| Note/Comment | Identify host proteins important for entry of Marburg virus | |
| References | Pubmed ID | 26596270 |