RNAi screen analysis of viral host genes
| Gene | vhfRNAi Accession | Vhf05846 |
| Gene Symbol | CATL1 | |
| Gene Description | Cathepsin L1 (EC 3.4.22.15) (Cathepsin L) (Major excreted protein) (MEP) [Cleaved into: Cathepsin L1 heavy chain; Cathepsin L1 light chain] | |
| Gene Name in Paper | CTSL | |
| Group | Restriction Factor | |
| Ensembl Gene ID | ENST00000340342 ENST00000343150 | |
| UniProt ID | P07711 | |
| Entrez Gene ID | 1514 | |
| GO | View | |
| Host | Organism | Homo sapiens |
| Virus | Virus full name | Marburgvirus |
| Virus Abbreviation | MARV | |
| Taxonomy | View | |
| Results | Phenotype | Inhibited infection |
| Hits Number* | 173 | |
| Confirmed Hits Number | 106 | |
| Score | ?3.92 | |
| Unit | z-score | |
| Methods | Assay Type | cell-based |
| BioModel Description | Human 293T embryonic kidney cells and human lung epithelial A549 cells | |
| Confirmatory Screen Description | Luciferase | |
| Primary Screen Description# | z-scores greater than 2 | |
| Note/Comment | Identify host proteins important for entry of Marburg virus | |
| References | Pubmed ID | 26596270 |