RNAi screen analysis of viral host genes
Gene | vhfRNAi Accession | Vhf04613 |
Gene Symbol | HSPD1 | |
Gene Description | 60 kDa heat shock protein, mitochondrial | |
Gene Name in Paper | HSPD1 | |
Group | Restriction Factor | |
Ensembl Gene ID | ENSG00000144381 | |
UniProt ID | P10809 | |
Entrez Gene ID | 3329 | |
GO | View | |
Host | Organism | Homo sapiens |
Virus | Virus full name | Influenza A virus |
Virus Abbreviation | IAV | |
Taxonomy | View | |
Results | Phenotype | Inhibited infection |
Hits Number* | 287 | |
Confirmed Hits Number | 168 | |
Score | NA | |
Unit | NA | |
Methods | Assay Type | cell-based |
BioModel Description | A549 human lung epithelial cells for screening a genome-wide siRNA library consisting of approximately 62,000 siRNAs targeting 17,000 annotated genes and 6,000 predicted genes | |
Confirmatory Screen Description | Confirmed hits were validated through siRNA and host cell viability determination by WST-1 assay | |
Primary Screen Description# | Z-scores below -2 | |
Note/Comment | Inhibited infection_total(168). Primary hits were validated using highly pathogenic avian-origin influenza A virus of the H5N1 subtype (A/Vietnam/1203/2004). | |
References | Pubmed ID | 20081832 |