RNAi screen analysis of viral host genes
Gene | vhfRNAi Accession | Vhf04396 |
Gene Symbol | SCAMP3 | |
Gene Description | Secretory carrier-associated membrane protein 3 | |
Gene Name in Paper | SCAMP3 | |
Group | Restriction Factor | |
Ensembl Gene ID | ENSG00000116521 | |
UniProt ID | O14828 | |
Entrez Gene ID | 10067 | |
GO | View | |
Host | Organism | Homo sapiens |
Virus | Virus full name | Human herpesvirus 1 |
Virus Abbreviation | HSV-1 | |
Taxonomy | View | |
Results | Phenotype | Inhibited infection |
Hits Number* | 358 | |
Confirmed Hits Number | 72 | |
Score | NA | |
Unit | NA | |
Methods | Assay Type | Cell-based |
BioModel Description | Epithelial Hela cell line for screening a druggable genome siRNA library (4 siRNAs per gene) targeting 7,237 human genes | |
Confirmatory Screen Description | Confirmed hits were defined as genes with ≥2 or more siRNAs giving the same or better replication slope than observed in the primary screen, or with <2 of 4 deconvoluted siRNAs reproduced the HSV-1 phenotype observed in the primary screen. | |
Primary Screen Description# | Hits were defined as the top 2.5% siRNA whose knockdown yielded strong inhibitory phenotypes. | |
Note/Comment | Inhibited infection(72) | |
References | Pubmed ID | 23950709 |