RNAi screen analysis of viral host genes
| Gene | vhfRNAi Accession | Vhf04101 |
| Gene Symbol | MRE11A | |
| Gene Description | Double-strand break repair protein MRE11A | |
| Gene Name in Paper | MRE11A | |
| Group | Others | |
| Ensembl Gene ID | ENSG00000020922 | |
| UniProt ID | P49959 | |
| Entrez Gene ID | 4361 | |
| GO | View | |
| Host | Organism | Homo sapiens |
| Virus | Virus full name | Human immunodeficiency virus 1 |
| Virus Abbreviation | HIV-1 | |
| Taxonomy | View | |
| Results | Phenotype | Others |
| Hits Number* | 390 | |
| Confirmed Hits Number | 232 | |
| Score | NA | |
| Unit | NA | |
| Methods | Assay Type | Cell-based |
| BioModel Description | HeLa P4/R5 cells (which contain ectopically expressed CD4 as well as an integrated HIV LTR-driven b-gal reporter) for screening a siRNA library targeting 19,709 genes with 22,329 pools (3 siRNAs per gene) | |
| Confirmatory Screen Description | Two hundred and ninety-one of these siRNAs were selected for validation using independent siRNAs. | |
| Primary Screen Description# | A hit was defined as siRNA that increased b-gal activity by at least 2-fold relative to negative controls. | |
| Note/Comment | Increased or inhibited infection(26) | |
| References | Pubmed ID | 18976975 |