RNAi screen analysis of viral host genes
| Gene | vhfRNAi Accession | Vhf03377 |
| Gene Symbol | TOP1M | |
| Gene Description | DNA topoisomerase I, mitochondrial (TOP1mt) (EC 5.99.1.2) | |
| Gene Name in Paper | TOP1M | |
| Group | Restriction Factor | |
| Ensembl Gene ID | ENST00000329245 ENST00000519148 ENST00000521193 ENST00000523676 | |
| UniProt ID | Q969P6 | |
| Entrez Gene ID | 116447 | |
| GO | View | |
| Host | Organism | Homo sapiens |
| Virus | Virus full name | Human immunodeficiency virus 1 |
| Virus Abbreviation | HIV-1 | |
| Taxonomy | View | |
| Results | Phenotype | Down regulated |
| Hits Number* | 3043 | |
| Confirmed Hits Number | 1083 | |
| Score | NA | |
| Unit | NA | |
| Methods | Assay Type | Cell-based |
| BioModel Description | CD4+ T-cell subsets enriched in cells exhibiting Th17 (CCR4+CCR6+), Th1 (CXCR3+CCR6?), Th2 (CCR4+CCR6?), and Th1Th17 (CXCR3+CCR6+) | |
| Confirmatory Screen Description | SYBR Green real-time RT-PCR | |
| Primary Screen Description# | Differentially expressed genes based on p value < 0.05 and fold change (FC, cut-off 1.3) | |
| Note/Comment | Identification of novel HIV-1 dependency factors | |
| References | Pubmed ID | 26654242 |