RNAi screen analysis of viral host genes
Gene | vhfRNAi Accession | Vhf03298 |
Gene Symbol | SOCS1 | |
Gene Description | Suppressor of cytokine signaling 1 (SOCS-1) (JAK-binding protein) (JAB) (STAT-induced STAT inhibitor 1) (SSI-1) (Tec-interacting protein 3) (TIP-3) | |
Gene Name in Paper | SOCS1 | |
Group | Restriction Factor | |
Ensembl Gene ID | ENST00000332029 | |
UniProt ID | O15524 | |
Entrez Gene ID | 8651 | |
GO | View | |
Host | Organism | Homo sapiens |
Virus | Virus full name | Human immunodeficiency virus 1 |
Virus Abbreviation | HIV-1 | |
Taxonomy | View | |
Results | Phenotype | Down regulated |
Hits Number* | 3043 | |
Confirmed Hits Number | 1083 | |
Score | NA | |
Unit | NA | |
Methods | Assay Type | Cell-based |
BioModel Description | CD4+ T-cell subsets enriched in cells exhibiting Th17 (CCR4+CCR6+), Th1 (CXCR3+CCR6?), Th2 (CCR4+CCR6?), and Th1Th17 (CXCR3+CCR6+) | |
Confirmatory Screen Description | SYBR Green real-time RT-PCR | |
Primary Screen Description# | Differentially expressed genes based on p value < 0.05 and fold change (FC, cut-off 1.3) | |
Note/Comment | Identification of novel HIV-1 dependency factors | |
References | Pubmed ID | 26654242 |