RNAi screen analysis of viral host genes
| Gene | vhfRNAi Accession | Vhf02998 |
| Gene Symbol | NALP2 | |
| Gene Description | NACHT, LRR and PYD domains-containing protein 2 (Nucleotide-binding site protein 1) (PYRIN domain and NACHT domain-containing protein 1) (PYRIN-containing APAF1-like protein 2) | |
| Gene Name in Paper | NALP2 | |
| Group | Restriction Factor | |
| Ensembl Gene ID | ENST00000339757 ENST00000391721 ENST00000427260 ENST00000448584 ENST00000537859 ENST00000543010 ENST00000611410 ENST00000611642 ENST00000611676 ENST00000611679 ENST00000611772 ENST00000613062 ENST00000613485 ENST00000613825 ENST00000613851 ENST00000615173 ENST00000615391 ENST00000615521 ENST00000616040 ENST00000616903 ENST00000616919 ENST00000618018 ENST00000618694 ENST00000618731 ENST00000618789 ENST00000618943 ENST00000619281 ENST00000619454 ENST00000619664 ENST00000619885 ENST00000621057 ENST00000621200 ENST00000621239 ENST00000621594 ENST00000622042 ENST00000622216 ENST00000622444 ENST00000622600 ENST00000622773 ENST00000622864 | |
| UniProt ID | Q9NX02 | |
| Entrez Gene ID | 55655 | |
| GO | View | |
| Host | Organism | Homo sapiens |
| Virus | Virus full name | Human immunodeficiency virus 1 |
| Virus Abbreviation | HIV-1 | |
| Taxonomy | View | |
| Results | Phenotype | Down regulated |
| Hits Number* | 3043 | |
| Confirmed Hits Number | 1083 | |
| Score | NA | |
| Unit | NA | |
| Methods | Assay Type | Cell-based |
| BioModel Description | CD4+ T-cell subsets enriched in cells exhibiting Th17 (CCR4+CCR6+), Th1 (CXCR3+CCR6?), Th2 (CCR4+CCR6?), and Th1Th17 (CXCR3+CCR6+) | |
| Confirmatory Screen Description | SYBR Green real-time RT-PCR | |
| Primary Screen Description# | Differentially expressed genes based on p value < 0.05 and fold change (FC, cut-off 1.3) | |
| Note/Comment | Identification of novel HIV-1 dependency factors | |
| References | Pubmed ID | 26654242 |