RNAi screen analysis of viral host genes
| Gene | vhfRNAi Accession | Vhf02844 |
| Gene Symbol | KI2L3 | |
| Gene Description | Killer cell immunoglobulin-like receptor 2DL3 (CD158 antigen-like family member B2) (KIR-023GB) (Killer inhibitory receptor cl 2-3) (MHC class I NK cell receptor) (NKAT2a) (NKAT2b) (Natural killer-associated transcript 2) (NKAT-2) (p58 natural killer cell receptor clone CL-6) (p58 NK receptor CL-6) (p58.2 MHC class-I-specific NK receptor) (CD antigen CD158b2) | |
| Gene Name in Paper | KI2L3 | |
| Group | Restriction Factor | |
| Ensembl Gene ID | ENST00000342376 ENST00000610407 ENST00000611207 ENST00000611369 ENST00000611821 ENST00000611990 ENST00000614792 ENST00000615091 ENST00000615739 ENST00000617150 ENST00000617242 ENST00000617404 ENST00000617593 ENST00000617790 ENST00000619702 ENST00000619995 ENST00000620549 ENST00000622644 | |
| UniProt ID | P43628 | |
| Entrez Gene ID | 3804 | |
| GO | View | |
| Host | Organism | Homo sapiens |
| Virus | Virus full name | Human immunodeficiency virus 1 |
| Virus Abbreviation | HIV-1 | |
| Taxonomy | View | |
| Results | Phenotype | Down regulated |
| Hits Number* | 3043 | |
| Confirmed Hits Number | 1083 | |
| Score | NA | |
| Unit | NA | |
| Methods | Assay Type | Cell-based |
| BioModel Description | CD4+ T-cell subsets enriched in cells exhibiting Th17 (CCR4+CCR6+), Th1 (CXCR3+CCR6?), Th2 (CCR4+CCR6?), and Th1Th17 (CXCR3+CCR6+) | |
| Confirmatory Screen Description | SYBR Green real-time RT-PCR | |
| Primary Screen Description# | Differentially expressed genes based on p value < 0.05 and fold change (FC, cut-off 1.3) | |
| Note/Comment | Identification of novel HIV-1 dependency factors | |
| References | Pubmed ID | 26654242 |