RNAi screen analysis of viral host genes
| Gene | vhfRNAi Accession | Vhf02504 |
| Gene Symbol | CC4L | |
| Gene Description | C-C motif chemokine 4-like (Lymphocyte activation gene 1 protein) (LAG-1) (Macrophage inflammatory protein 1-beta) (MIP-1-beta) (Monocyte adherence-induced protein 5-alpha) (Small-inducible cytokine A4-like) | |
| Gene Name in Paper | CC4L | |
| Group | Restriction Factor | |
| Ensembl Gene ID | ENST00000610565 ENST00000613173 ENST00000613828 ENST00000614182 ENST00000615418 ENST00000616100 ENST00000616729 ENST00000617405 ENST00000617416 ENST00000620055 ENST00000620063 ENST00000620098 ENST00000620250 ENST00000620576 ENST00000620708 ENST00000620732 ENST00000622783 ENST00000631554 ENST00000631660 ENST00000631768 ENST00000631782 ENST00000631808 ENST00000632416 ENST00000632480 ENST00000632699 ENST00000632710 ENST00000633309 ENST00000633550 ENST00000633849 ENST00000633897 ENST00000633927 ENST00000634027 ENST00000634078 ENST00000634191 | |
| UniProt ID | Q8NHW4 | |
| Entrez Gene ID | 388372;9560 | |
| GO | View | |
| Host | Organism | Homo sapiens |
| Virus | Virus full name | Human immunodeficiency virus 1 |
| Virus Abbreviation | HIV-1 | |
| Taxonomy | View | |
| Results | Phenotype | Down regulated |
| Hits Number* | 3043 | |
| Confirmed Hits Number | 1083 | |
| Score | NA | |
| Unit | NA | |
| Methods | Assay Type | Cell-based |
| BioModel Description | CD4+ T-cell subsets enriched in cells exhibiting Th17 (CCR4+CCR6+), Th1 (CXCR3+CCR6?), Th2 (CCR4+CCR6?), and Th1Th17 (CXCR3+CCR6+) | |
| Confirmatory Screen Description | SYBR Green real-time RT-PCR | |
| Primary Screen Description# | Differentially expressed genes based on p value < 0.05 and fold change (FC, cut-off 1.3) | |
| Note/Comment | Identification of novel HIV-1 dependency factors | |
| References | Pubmed ID | 26654242 |