RNAi screen analysis of viral host genes
| Gene | vhfRNAi Accession | Vhf01609 |
| Gene Symbol | BCKDHB | |
| Gene Description | 2-oxoisovalerate dehydrogenase subunit beta, mitochondrial | |
| Gene Name in Paper | BCKDHB | |
| Group | Restriction Factor | |
| Ensembl Gene ID | ENSG00000083123 | |
| UniProt ID | P21953 | |
| Entrez Gene ID | 594 | |
| GO | View | |
| Host | Organism | Homo sapiens |
| Virus | Virus full name | Hepatitis C virus |
| Virus Abbreviation | HCV | |
| Taxonomy | View | |
| Results | Phenotype | Inhibited infection |
| Hits Number* | 236 | |
| Confirmed Hits Number | 96 | |
| Score | 2.758872778 | |
| Unit | Fold change | |
| Methods | Assay Type | Cell-based |
| BioModel Description | Huh7/Rep-Feo replicon cell line for screening a whole-genome siRNA library (4 siRNAs per gene) containing 21,094 siRNA pools targeting the entire human NCBI RefSeq transcript database | |
| Confirmatory Screen Description | 186 pools (87.7%) had at least one siRNA that decrease HCV replication by: 2 SD compared to a nontargeting control siRNA | |
| Primary Screen Description# | Two siRNAs out of four decrease HCV replication by: 2 SD | |
| Note/Comment | Inhibited infection(96) | |
| References | Pubmed ID | 19286138 |