RNAi screen analysis of viral host genes
| Gene | vhfRNAi Accession | Vhf01521 |
| Gene Symbol | CHRNA2 | |
| Gene Description | Neuronal acetylcholine receptor subunit alpha-2 | |
| Gene Name in Paper | CHRNA2 | |
| Group | Restriction Factor | |
| Ensembl Gene ID | ENSG00000120903 | |
| UniProt ID | Q15822 | |
| Entrez Gene ID | 1135 | |
| GO | View | |
| Host | Organism | Homo sapiens |
| Virus | Virus full name | Dengue virus 2 |
| Virus Abbreviation | DEN-2 | |
| Taxonomy | View | |
| Results | Phenotype | Inhibited infection |
| Hits Number* | 116 | |
| Confirmed Hits Number | 40 | |
| Score | 3 | |
| Unit | Fold Change | |
| Methods | Assay Type | Cell-based |
| BioModel Description | HuH-7 cells using two siRNAs (Qiagen) | |
| Confirmatory Screen Description | Validation was done by siRNA in HuH-7 cells with results of 1.5 fold inhibition with a p-value <0.05 as confirmed hits. All confirmed hits are human genes | |
| Primary Screen Description# | 1.5 fold inhibition with a p-value <0.05 | |
| Note/Comment | Inhibited infection(40). The 116 genes are from Drosophila melanogaster, which have 82 readily recognizable human homologues. | |
| References | Pubmed ID | 19396146 |