Vhf01498 details

Gene vhfRNAi AccessionVhf01498
Gene SymbolABCC10
Gene DescriptionMultidrug resistance-associated protein 7
Gene Name in PaperABCC10
GroupRestriction Factor
Ensembl Gene IDENSG00000124574 
UniProt IDQ5T3U5
Entrez Gene ID89845
GOView
Host OrganismHomo sapiens
Virus Virus full nameBorna disease virus
Virus AbbreviationBDV
TaxonomyView
Results PhenotypeInhibited infection
Hits Number*58
Confirmed Hits Number34
Score2.69
UnitFold change
Methods Assay Type Cell-based
BioModel DescriptionOl cell line (an established human oligodendroglial cell line) for a small interfering RNA (siRNA)-based high-throughput screen (HTS)of 5,516 genes
Confirmatory Screen DescriptionData were obtained from four independent replicates for each siRNA. 47 siRNAs were selected among the 123 gene-specific siRNAs, that consistently inhibited infection with rVSV?G*/BDVG.
Primary Screen Description#Candidate genes with a score higher than two and at least two siRNA with a P value of < 0.05 were selected
Note/CommentCommon genes for inhibition of BDV and VSV cell entry(15)
References Pubmed ID20071576
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*Replicates that are beyond 2-3 standard deviation values from the mean (Sharma 2009)
#A strong signal/background ratio with low variation in the assay (Zhang 1999)