RNAi screen analysis of viral host genes
| Gene | vhfRNAi Accession | Vhf01471 |
| Gene Symbol | IARS2 | |
| Gene Description | Isoleucine--tRNA ligase, mitochondrial | |
| Gene Name in Paper | NA | |
| Group | Restriction Factor | |
| Ensembl Gene ID | ENSG00000067704 | |
| UniProt ID | Q9NSE4 | |
| Entrez Gene ID | 55699 | |
| GO | View | |
| Host | Organism | Homo sapiens |
| Virus | Virus full name | Borna disease virus |
| Virus Abbreviation | BDV | |
| Taxonomy | View | |
| Results | Phenotype | Inhibited infection |
| Hits Number* | 58 | |
| Confirmed Hits Number | 34 | |
| Score | NA | |
| Unit | NA | |
| Methods | Assay Type | Cell-based |
| BioModel Description | Ol cell line (an established human oligodendroglial cell line) for a small interfering RNA (siRNA)-based high-throughput screen (HTS)of 5,516 genes | |
| Confirmatory Screen Description | Data were obtained from four independent replicates for each siRNA. 47 siRNAs were selected among the 123 gene-specific siRNAs, that consistently inhibited infection with rVSV?G*/BDVG. | |
| Primary Screen Description# | Candidate genes with a score higher than two and at least two siRNA with a P value of < 0.05 were selected | |
| Note/Comment | specific inhibition of BDV G-mediated cell entry(19) | |
| References | Pubmed ID | 20071576 |