RNAi screen analysis of viral host genes
Gene | vhfRNAi Accession | Vhf01465 |
Gene Symbol | EXT1 | |
Gene Description | Exostosin-1 (EC 2.4.1.224) (EC 2.4.1.225) (Glucuronosyl-N-acetylglucosaminyl-proteoglycan/N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase) (Multiple exostoses protein 1) (Putative tumor suppressor protein EXT1) | |
Gene Name in Paper | EXT1 | |
Group | Restriction Factor | |
Ensembl Gene ID | ENST00000378204 | |
UniProt ID | Q16394 | |
Entrez Gene ID | 2131 | |
GO | View | |
Host | Organism | Homo sapiens |
Virus | Virus full name | Avian influenza virus |
Virus Abbreviation | AIV | |
Taxonomy | View | |
Results | Phenotype | Inhibited infection |
Hits Number* | 109 | |
Confirmed Hits Number | 42 | |
Score | 1.35 | |
Unit | siRNA score | |
Methods | Assay Type | cell-based |
BioModel Description | Human 293T embryonic kidney cells and human lung epithelial A549 cells | |
Confirmatory Screen Description | Luciferase | |
Primary Screen Description# | z-scores greater than 2 | |
Note/Comment | Identify host proteins important for H5N1 influenza virus | |
References | Pubmed ID | 26596270 |