RNAi screen analysis of viral host genes
| Gene | vhfRNAi Accession | Vhf01334 |
| Gene Symbol | ITCH | |
| Gene Description | E3 ubiquitin-protein ligase Itchy homolog (Itch) (EC 6.3.2.-) (Atrophin-1-interacting protein 4) (AIP4) (NFE2-associated polypeptide 1) (NAPP1) | |
| Gene Name in Paper | ITCH | |
| Group | Host Factor | |
| Ensembl Gene ID | ENST00000262650 ENST00000374864 ENST00000535650 ENST00000610336 ENST00000621101 | |
| UniProt ID | Q96J02 | |
| Entrez Gene ID | 83737 | |
| GO | View | |
| Host | Organism | Homo sapiens |
| Virus | Virus full name | Adeno-associated virus |
| Virus Abbreviation | AAV | |
| Taxonomy | View | |
| Results | Phenotype | Increased transduction |
| Hits Number* | 1483 | |
| Confirmed Hits Number | 515 | |
| Score | NA | |
| Unit | NA | |
| Methods | Assay Type | cell-based |
| BioModel Description | HEK293 and HeLa cells | |
| Confirmatory Screen Description | Immunofluorescence | |
| Primary Screen Description# | log 2 Luc/AB ratio >2 | |
| Note/Comment | Host restriction factors critical for in vivo AAV transduction | |
| References | Pubmed ID | 26305933 |