RNAi screen analysis of viral host genes
| Gene | vhfRNAi Accession | Vhf01322 |
| Gene Symbol | LRC8B | |
| Gene Description | Volume-regulated anion channel subunit LRRC8B (Leucine-rich repeat-containing protein 8B) (T-cell activation leucine repeat-rich protein) (TA-LRRP) | |
| Gene Name in Paper | TA-LRRP | |
| Group | Host Factor | |
| Ensembl Gene ID | ENST00000330947 ENST00000439853 | |
| UniProt ID | Q6P9F7 | |
| Entrez Gene ID | 23507 | |
| GO | View | |
| Host | Organism | Homo sapiens |
| Virus | Virus full name | Adeno-associated virus |
| Virus Abbreviation | AAV | |
| Taxonomy | View | |
| Results | Phenotype | Increased transduction |
| Hits Number* | 1483 | |
| Confirmed Hits Number | 515 | |
| Score | NA | |
| Unit | NA | |
| Methods | Assay Type | cell-based |
| BioModel Description | HEK293 and HeLa cells | |
| Confirmatory Screen Description | Immunofluorescence | |
| Primary Screen Description# | log 2 Luc/AB ratio >2 | |
| Note/Comment | Host restriction factors critical for in vivo AAV transduction | |
| References | Pubmed ID | 26305933 |