RNAi screen analysis of viral host genes
| Gene | vhfRNAi Accession | Vhf01036 |
| Gene Symbol | YMEL1 | |
| Gene Description | ATP-dependent zinc metalloprotease YME1L1 (EC 3.4.24.-) (ATP-dependent metalloprotease FtsH1) (Meg-4) (Presenilin-associated metalloprotease) (PAMP) (YME1-like protein 1) | |
| Gene Name in Paper | YME1L1 | |
| Group | Host Factor | |
| Ensembl Gene ID | ENST00000326799 ENST00000376016 ENST00000613434 | |
| UniProt ID | Q96TA2 | |
| Entrez Gene ID | 10730 | |
| GO | View | |
| Host | Organism | Homo sapiens |
| Virus | Virus full name | Adeno-associated virus |
| Virus Abbreviation | AAV | |
| Taxonomy | View | |
| Results | Phenotype | Increased transduction |
| Hits Number* | 1483 | |
| Confirmed Hits Number | 515 | |
| Score | NA | |
| Unit | NA | |
| Methods | Assay Type | cell-based |
| BioModel Description | HEK293 and HeLa cells | |
| Confirmatory Screen Description | Immunofluorescence | |
| Primary Screen Description# | log 2 Luc/AB ratio >2 | |
| Note/Comment | Host restriction factors critical for in vivo AAV transduction | |
| References | Pubmed ID | 26305933 |