RNAi screen analysis of viral host genes
| Gene | vhfRNAi Accession | Vhf00998 |
| Gene Symbol | BACE1 | |
| Gene Description | Beta-secretase 1 (EC 3.4.23.46) (Aspartyl protease 2) (ASP2) (Asp 2) (Beta-site amyloid precursor protein cleaving enzyme 1) (Beta-site APP cleaving enzyme 1) (Memapsin-2) (Membrane-associated aspartic protease 2) | |
| Gene Name in Paper | BACE1 | |
| Group | Host Factor | |
| Ensembl Gene ID | ENST00000313005 ENST00000392937 ENST00000428381 ENST00000445823 ENST00000510630 ENST00000513780 | |
| UniProt ID | P56817 | |
| Entrez Gene ID | 23621 | |
| GO | View | |
| Host | Organism | Homo sapiens |
| Virus | Virus full name | Adeno-associated virus |
| Virus Abbreviation | AAV | |
| Taxonomy | View | |
| Results | Phenotype | Increased transduction |
| Hits Number* | 1483 | |
| Confirmed Hits Number | 515 | |
| Score | NA | |
| Unit | NA | |
| Methods | Assay Type | cell-based |
| BioModel Description | HEK293 and HeLa cells | |
| Confirmatory Screen Description | Immunofluorescence | |
| Primary Screen Description# | log 2 Luc/AB ratio >2 | |
| Note/Comment | Host restriction factors critical for in vivo AAV transduction | |
| References | Pubmed ID | 26305933 |