RNAi screen analysis of viral host genes
Gene | vhfRNAi Accession | Vhf00747 |
Gene Symbol | FXL12 | |
Gene Description | F-box/LRR-repeat protein 12 (F-box and leucine-rich repeat protein 12) (F-box protein FBL12) | |
Gene Name in Paper | FBXL12 | |
Group | Restriction Factor | |
Ensembl Gene ID | ENST00000247977 ENST00000585379 ENST00000591009 | |
UniProt ID | Q9NXK8 | |
Entrez Gene ID | 54850 | |
GO | View | |
Host | Organism | Homo sapiens |
Virus | Virus full name | Adeno-associated virus |
Virus Abbreviation | AAV | |
Taxonomy | View | |
Results | Phenotype | Inhibited transduction |
Hits Number* | 1483 | |
Confirmed Hits Number | 968 | |
Score | NA | |
Unit | NA | |
Methods | Assay Type | cell-based |
BioModel Description | HEK293 and HeLa cells | |
Confirmatory Screen Description | Immunofluorescence | |
Primary Screen Description# | log 2 Luc/AB ratio >2 | |
Note/Comment | Host restriction factors critical for in vivo AAV transduction | |
References | Pubmed ID | 26305933 |