RNAi screen analysis of viral host genes
| Gene | vhfRNAi Accession | Vhf00503 |
| Gene Symbol | CASP8 | |
| Gene Description | Caspase-8 (CASP-8) (EC 3.4.22.61) (Apoptotic cysteine protease) (Apoptotic protease Mch-5) (CAP4) (FADD-homologous ICE/ced-3-like protease) (FADD-like ICE) (FLICE) (ICE-like apoptotic protease 5) (MORT1-associated ced-3 homolog) (MACH) [Cleaved into: Caspase-8 subunit p18; Caspase-8 subunit p10] | |
| Gene Name in Paper | CASP8 | |
| Group | Restriction Factor | |
| Ensembl Gene ID | ENST00000264274 ENST00000264275 ENST00000323492 ENST00000358485 ENST00000392258 ENST00000392263 ENST00000432109 | |
| UniProt ID | Q14790 | |
| Entrez Gene ID | 841 | |
| GO | View | |
| Host | Organism | Homo sapiens |
| Virus | Virus full name | Adeno-associated virus |
| Virus Abbreviation | AAV | |
| Taxonomy | View | |
| Results | Phenotype | Inhibited transduction |
| Hits Number* | 1483 | |
| Confirmed Hits Number | 968 | |
| Score | NA | |
| Unit | NA | |
| Methods | Assay Type | cell-based |
| BioModel Description | HEK293 and HeLa cells | |
| Confirmatory Screen Description | Immunofluorescence | |
| Primary Screen Description# | log 2 Luc/AB ratio >2 | |
| Note/Comment | Host restriction factors critical for in vivo AAV transduction | |
| References | Pubmed ID | 26305933 |