RNAi screen analysis of viral host genes
| Gene | vhfRNAi Accession | Vhf00498 |
| Gene Symbol | PTPA | |
| Gene Description | Serine/threonine-protein phosphatase 2A activator (EC 5.2.1.8) (PP2A, subunit B', PR53 isoform) (Phosphotyrosyl phosphatase activator) (PTPA) (Serine/threonine-protein phosphatase 2A regulatory subunit 4) (Serine/threonine-protein phosphatase 2A regulatory subunit B') | |
| Gene Name in Paper | PPP2R4 | |
| Group | Restriction Factor | |
| Ensembl Gene ID | ENST00000337738 ENST00000355007 ENST00000357197 ENST00000358994 ENST00000393370 | |
| UniProt ID | Q15257 | |
| Entrez Gene ID | 5524 | |
| GO | View | |
| Host | Organism | Homo sapiens |
| Virus | Virus full name | Adeno-associated virus |
| Virus Abbreviation | AAV | |
| Taxonomy | View | |
| Results | Phenotype | Inhibited transduction |
| Hits Number* | 1483 | |
| Confirmed Hits Number | 968 | |
| Score | NA | |
| Unit | NA | |
| Methods | Assay Type | cell-based |
| BioModel Description | HEK293 and HeLa cells | |
| Confirmatory Screen Description | Immunofluorescence | |
| Primary Screen Description# | log 2 Luc/AB ratio >2 | |
| Note/Comment | Host restriction factors critical for in vivo AAV transduction | |
| References | Pubmed ID | 26305933 |