RNAi screen analysis of viral host genes
| Gene | vhfRNAi Accession | Vhf00344 |
| Gene Symbol | PTGR1 | |
| Gene Description | Prostaglandin reductase 1 (PRG-1) (EC 1.3.1.-) (15-oxoprostaglandin 13-reductase) (EC 1.3.1.48) (NADP-dependent leukotriene B4 12-hydroxydehydrogenase) (EC 1.3.1.74) | |
| Gene Name in Paper | LTB4DH | |
| Group | Restriction Factor | |
| Ensembl Gene ID | ENST00000309195 ENST00000407693 ENST00000538962 | |
| UniProt ID | Q14914 | |
| Entrez Gene ID | 22949 | |
| GO | View | |
| Host | Organism | Homo sapiens |
| Virus | Virus full name | Adeno-associated virus |
| Virus Abbreviation | AAV | |
| Taxonomy | View | |
| Results | Phenotype | Inhibited transduction |
| Hits Number* | 1483 | |
| Confirmed Hits Number | 968 | |
| Score | NA | |
| Unit | NA | |
| Methods | Assay Type | cell-based |
| BioModel Description | HEK293 and HeLa cells | |
| Confirmatory Screen Description | Immunofluorescence | |
| Primary Screen Description# | log 2 Luc/AB ratio >2 | |
| Note/Comment | Host restriction factors critical for in vivo AAV transduction | |
| References | Pubmed ID | 26305933 |