RNAi screen analysis of viral host genes
| Gene | vhfRNAi Accession | Vhf00160 |
| Gene Symbol | SDF1 | |
| Gene Description | Stromal cell-derived factor 1 (SDF-1) (hSDF-1) (C-X-C motif chemokine 12) (Intercrine reduced in hepatomas) (IRH) (hIRH) (Pre-B cell growth-stimulating factor) (PBSF) [Cleaved into: SDF-1-beta(3-72); SDF-1-alpha(3-67)] | |
| Gene Name in Paper | CXCL12 | |
| Group | Restriction Factor | |
| Ensembl Gene ID | ENST00000343575 ENST00000374426 ENST00000374429 ENST00000395793 ENST00000395794 ENST00000395795 | |
| UniProt ID | P48061 | |
| Entrez Gene ID | 6387 | |
| GO | View | |
| Host | Organism | Homo sapiens |
| Virus | Virus full name | Adeno-associated virus |
| Virus Abbreviation | AAV | |
| Taxonomy | View | |
| Results | Phenotype | Inhibited transduction |
| Hits Number* | 1483 | |
| Confirmed Hits Number | 968 | |
| Score | NA | |
| Unit | NA | |
| Methods | Assay Type | cell-based |
| BioModel Description | HEK293 and HeLa cells | |
| Confirmatory Screen Description | Immunofluorescence | |
| Primary Screen Description# | log 2 Luc/AB ratio >2 | |
| Note/Comment | Host restriction factors critical for in vivo AAV transduction | |
| References | Pubmed ID | 26305933 |