RNAi screen analysis of viral host genes
| Gene | vhfRNAi Accession | Vhf00070 |
| Gene Symbol | MCCA | |
| Gene Description | Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial (MCCase subunit alpha) (EC 6.4.1.4) (3-methylcrotonyl-CoA carboxylase 1) (3-methylcrotonyl-CoA carboxylase biotin-containing subunit) (3-methylcrotonyl-CoA:carbon dioxide ligase subunit alpha) | |
| Gene Name in Paper | MCCC1 | |
| Group | Restriction Factor | |
| Ensembl Gene ID | ENST00000265594 | |
| UniProt ID | Q96RQ3 | |
| Entrez Gene ID | 56922 | |
| GO | View | |
| Host | Organism | Homo sapiens |
| Virus | Virus full name | Adeno-associated virus |
| Virus Abbreviation | AAV | |
| Taxonomy | View | |
| Results | Phenotype | Inhibited transduction |
| Hits Number* | 1483 | |
| Confirmed Hits Number | 968 | |
| Score | NA | |
| Unit | NA | |
| Methods | Assay Type | cell-based |
| BioModel Description | HEK293 and HeLa cells | |
| Confirmatory Screen Description | Immunofluorescence | |
| Primary Screen Description# | log 2 Luc/AB ratio >2 | |
| Note/Comment | Host restriction factors critical for in vivo AAV transduction | |
| References | Pubmed ID | 26305933 |