RNAi screen analysis of viral host genes
Reference | Disease | Gene | SNP ID | SNP | p-value | Virus |
---|---|---|---|---|---|---|
Reference | Disease | Gene | SNP ID | SNP | p-value | Virus |
23382691 | IgG glycosylation | ABCF2 | 10061 | rs1122979 | 2.00E-10 | PV |
24024966 | Periodontitis (CDC/AAP) | ACTN2 | 88 | rs12048046 | 3.00E-06 | PV |
23583979 | Heart rate | ACTN4 | 81 | rs11083475 | 2.00E-06 | PV |
23456092 | Alcohol dependence | ADH1B | 125 | rs1229984 | 3.00E-21 | PV |
22484627 | Obesity | ALPK1 | 80216 | rs4833407 | 1.00E-06 | PV |
21799462 | Epirubicin-induced leukopenia | ALPK1 | 80216 | rs6838440 | 3.00E-06 | PV |
21685187 | Chronic obstructive pulmonary disease | ANXA5 | 308 | rs55645543 | 5.00E-07 | PV |
24023260 | Lipid traits | APOA5 | 116519 | rs662799 | 6.00E-24 | PV |
22286219 | Lipid metabolism phenotypes | APOA5 | 116519 | rs651821 | 8.00E-20 | PV |
22286219 | Lipid metabolism phenotypes | APOE | 348 | rs7412 | 3.00E-58 | PV |
20668430 | Glomerulosclerosis | APOL1 | 8542 | rs2239785 | 5.00E-13 | PV |
21983787 | Melanoma | ATM | 472 | rs1801516 | 3.00E-09 | PV |
21841780 | Graves' disease | BACH2 | 60468 | rs370409 | 2.00E-06 | PV |
20190752 | Celiac disease | BACH2 | 60468 | rs10806425 | 4.00E-10 | PV |
22139419 | Platelet counts | BAZ2A | 11176 | rs941207 | 2.00E-10 | PV |
24026423 | Platelet counts | BET1L | 51272 | rs11602954 | 5.00E-12 | PV |
22610502 | Immune response to smallpox vaccine (IL-6) | BLK | 640 | rs2255327 | 3.00E-07 | PV |
21452313 | Rheumatoid arthritis | BLK | 640 | rs1600249 | 5.00E-06 | PV |
19165918 | Systemic lupus erythematosus | BLK | 640 | rs2618476 | 2.00E-08 | PV |
23535033 | Alzheimer's disease (cognitive decline) | BZW2 | 28969 | rs58370486 | 6.00E-11 | PV |
23251661 | Obesity-related traits | CADM1 | 23705 | rs220836 | 6.00E-06 | PV |
20062060 | PR interval | CAV1 | 857 | rs3807989 | 4.00E-28 | PV |
23263863 | Mean corpuscular volume | CCND3 | 896 | rs3218097 | 9.00E-08 | PV |
21102463 | Crohn's disease | CD244 | 51744 | rs4656940 | 6.00E-07 | PV |
23958962 | Cocaine dependence | CDK1 | 983 | rs2456778 | 5.00E-06 | PV |
23259602 | Dental caries | CDKN3 | 1033 | rs4251631 | 2.00E-07 | PV |
23505323 | HDL cholesterol | CETP | 1071 | rs1532624 | 1.00E-24 | PV |
20031564 | HDL cholesterol | CETP | 1071 | rs1800775 | 4.00E-93 | PV |
23128233 | Ulcerative colitis | CHP1 | 11261 | rs28374715 | 2.00E-08 | PV |
18957941 | Personality dimensions | CLOCK | 9575 | rs6832769 | 2.00E-06 | PV |
24105470 | Adiponectin levels | CMIP | 80790 | rs2925979 | 2.00E-10 | PV |
22158537 | Type 2 diabetes | CMIP | 80790 | rs16955379 | 3.00E-07 | PV |
23362303 | Stearic acid (18:0) plasma levels | CNN3 | 1266 | rs860873 | 2.00E-14 | PV |
22726844 | QT interval | CNOT1 | 23019 | rs37060 | 1.00E-07 | PV |
19305408 | QT interval | CNOT1 | 23019 | rs37062 | 3.00E-25 | PV |
23251661 | Obesity-related traits | CPEB4 | 80315 | rs1106693 | 2.00E-06 | PV |
23128233 | Crohn's disease | CPEB4 | 80315 | rs17695092 | 5.00E-09 | PV |
20935629 | Waist-hip ratio | CPEB4 | 80315 | rs6861681 | 2.00E-09 | PV |
23149075 | Response to fenofibrate (adiponectin levels) | DDX54 | 79039 | rs2384207 | 5.00E-08 | PV |
23449627 | Pubertal anthropometrics | DDX55 | 57696 | rs786425 | 3.00E-06 | PV |
19176441 | Response to treatment for acute lymphoblastic leukemia | DGKB | 1607 | rs6971925 | 3.00E-06 | PV |
24068962 | Calcium levels | DGKD | 8527 | rs1550532 | 8.00E-11 | PV |
20705733 | Calcium levels | DGKD | 8527 | rs838705 | 9.00E-06 | PV |
23251661 | Obesity-related traits | DLG2 | 1740 | rs2116483 | 8.00E-06 | PV |
22544364 | Wilms tumor | DLG2 | 1740 | rs790356 | 4.00E-15 | PV |
22359512 | Phospholipid levels (plasma) | DLG2 | 1740 | rs17148090 | 4.00E-08 | PV |
18464913 | Protein quantitative trait loci | DLG2 | 1740 | rs3885683 | 8.00E-06 | PV |
17052657 | Parkinson's disease | DLG2 | 1740 | rs10501570 | 7.00E-06 | PV |
23760081 | Chronic hepatitis B infection | EHMT2 | 10919 | rs652888 | 7.00E-13 | PV |
23266558 | Crohn's disease | ELF1 | 1997 | rs7329174 | 8.00E-09 | PV |
23535729 | Breast cancer | EMID1 | 129080 | rs132390 | 3.00E-09 | PV |
23568457 | Eating disorders | EMP2 | 2013 | rs2221433 | 5.00E-06 | PV |
23319000 | Metabolite levels (MHPG) | EMP2 | 2013 | rs6498068 | 6.00E-06 | PV |
20732626 | Attention deficit hyperactivity disorder | EMP2 | 2013 | rs11074889 | 7.00E-07 | PV |
23251661 | Obesity-related traits | ERBB3 | 2065 | rs34379766 | 5.00E-07 | PV |
21829393 | Type 1 diabetes autoantibodies | ERBB3 | 2065 | rs2292239 | 3.00E-27 | PV |
23551011 | Preeclampsia | ERP44 | 23071 | rs7028939 | 3.00E-06 | PV |
23251661 | Obesity-related traits | ETS1 | 2113 | rs7117932 | 8.00E-06 | PV |
20190752 | Celiac disease | ETS1 | 2113 | rs11221332 | 5.00E-16 | PV |
20169177 | Systemic lupus erythematosus | ETS1 | 2113 | rs1128334 | 2.00E-11 | PV |
23824729 | Homocysteine levels | FANCA | 2175 | rs12921383 | 8.00E-11 | PV |
23770605 | Chronic lymphocytic leukemia | FAS | 355 | rs4406737 | 1.00E-14 | PV |
20694011 | Immunoglobulin A | FAS | 355 | rs2234978 | 6.00E-06 | PV |
22688191 | Schizophrenia | FEZ1 | 9638 | rs11220082 | 7.00E-07 | PV |
21804548 | Asthma | GAB1 | 2549 | rs3805236 | 7.00E-08 | PV |
20881960 | Height | GIT1 | 28964 | rs3110496 | 7.00E-09 | PV |
23535732 | Prostate cancer | GRHL1 | 29841 | rs11902236 | 3.00E-08 | PV |
23251661 | Obesity-related traits | GRK5 | 2869 | rs1397615 | 2.00E-06 | PV |
22961080 | Type 2 diabetes | GRK5 | 2869 | rs10886471 | 7.00E-09 | PV |
24097068 | HDL cholesterol | GSK3B | 2932 | rs6805251 | 1.00E-08 | PV |
22939635 | C-reactive protein | HNF1A | 6927 | rs2259816 | 3.00E-10 | PV |
21203500 | N-glycan levels | HNF1A | 6927 | rs735396 | 4.00E-08 | PV |
24097068 | Cholesterol, total | HNF1A | 6927 | rs1169288 | 4.00E-17 | PV |
23844046 | C-reactive protein | HNF1A | 6927 | rs1183910 | 4.00E-12 | PV |
23263486 | Urate levels | HNF1A | 6927 | rs2244608 | 8.00E-08 | PV |
22939635 | C-reactive protein | HNF1A | 6927 | rs7979473 | 1.00E-10 | PV |
22788528 | C-reactive protein and white blood cell count | HNF1A | 6927 | rs2393791 | 3.00E-09 | PV |
22001757 | Liver enzyme levels (gamma-glutamyl transferase) | HNF1A | 6927 | rs7310409 | 7.00E-45 | PV |
18439552 | C-reactive protein | HNF1A | 6927 | rs1169310 | 2.00E-08 | PV |
23535730 | Ovarian cancer | HNF1B | 6928 | rs757210 | 8.00E-10 | PV |
21107309 | Reasoning | HUNK | 30811 | rs2833556 | 5.00E-07 | PV |
21533024 | Soluble ICAM-1 | ICAM1 | 3383 | rs1799969 | 1.00E-120 | PV |
23512250 | Acute lymphoblastic leukemia (childhood) | IKZF1 | 10320 | rs6964969 | 2.00E-29 | PV |
19684603 | Acute lymphoblastic leukemia (childhood) | IKZF1 | 10320 | rs11978267 | 8.00E-11 | PV |
22139419 | Platelet counts | IRF1 | 3659 | rs2070729 | 1.00E-10 | PV |
22863734 | Orofacial clefts | IRF6 | 3664 | rs861020 | 3.00E-12 | PV |
22139419 | Platelet counts | ITPK1 | 3705 | rs8006385 | 1.00E-10 | PV |
20881960 | Height | ITPR3 | 3710 | rs4711336 | 3.00E-08 | PV |
20062063 | Electrocardiographic traits | KCNE1 | 3753 | rs727957 | 2.00E-12 | PV |
23870195 | Coronary artery calcification | KCNQ3 | 3786 | rs978152 | 8.00E-06 | PV |
23472165 | Endometriosis | KSR2 | 283455 | rs10431397 | 7.00E-06 | PV |
22589738 | Visceral adipose tissue adjusted for BMI | KSR2 | 283455 | rs4304868 | 8.00E-06 | PV |
19260141 | Biochemical measures | KSR2 | 283455 | rs10444502 | 6.00E-06 | PV |
19260141 | Biochemical measures | KSR2 | 283455 | rs4767631 | 6.00E-07 | PV |
21408207 | Systemic lupus erythematosus | LAMC2 | 3918 | rs525410 | 6.00E-07 | PV |
21347282 | Coronary heart disease | LAMC2 | 3918 | rs1028771 | 4.00E-06 | PV |
23844046 | C-reactive protein | LEPR | 3953 | rs10889569 | 9.00E-09 | PV |
23563609 | Obesity (early onset extreme) | LEPR | 3953 | rs11208659 | 2.00E-09 | PV |
22939635 | C-reactive protein | LEPR | 3953 | rs1805096 | 2.00E-09 | PV |
20167575 | Soluble leptin receptor levels | LEPR | 3953 | rs1751492 | 6.00E-13 | PV |
19567438 | C-reactive protein | LEPR | 3953 | rs6700896 | 3.00E-14 | PV |
22581228 | Fasting glucose-related traits (interaction with BMI) | MADD | 8567 | rs7944584 | 4.00E-12 | PV |
21873549 | Proinsulin levels | MADD | 8567 | rs10501320 | 1.00E-88 | PV |
21873549 | Proinsulin levels | MADD | 8567 | rs10838687 | 7.00E-12 | PV |
21833088 | Multiple sclerosis | MANBA | 4126 | rs228614 | 1.00E-07 | PV |
22949513 | Epilepsy (generalized) | MAST4 | 375449 | rs39861 | 3.00E-07 | PV |
20009918 | Carotid atherosclerosis in HIV infection | MAST4 | 375449 | rs1697137 | 2.00E-06 | PV |
23572186 | Bone mineral density | MEF2C | 4208 | rs11951031 | 9.00E-09 | PV |
23400010 | Thiazide-induced adverse metabolic effects in hypertensive patients | MEF2C | 4208 | rs17560407 | 5.00E-07 | PV |
22139419 | Mean platelet volume | MEF2C | 4208 | rs4521516 | 2.00E-09 | PV |
22139419 | Platelet counts | MEF2C | 4208 | rs700585 | 1.00E-09 | PV |
17903302 | Tonometry | MEF2C | 4208 | rs770189 | 3.00E-06 | PV |
22001756 | Dengue shock syndrome | MICB | 4277 | rs3132468 | 4.00E-11 | PV |
21946350 | Pulmonary function | MICB | 4277 | rs2855812 | 2.00E-07 | PV |
23555189 | PCA3 expression level | MSMB | 4477 | rs10993994 | 1.00E-09 | PV |
23583980 | Interstitial lung disease | MUC2 | 4583 | rs7934606 | 7.00E-34 | PV |
20395239 | Optic disc size (rim) | MYH9 | 4627 | rs735854 | 9.00E-06 | PV |
22916037 | Metabolite levels | MYO1E | 4643 | rs2306786 | 1.00E-10 | PV |
24047820 | Social communication problems | MYO1E | 4643 | rs4218 | 1.00E-07 | PV |
23534349 | PR interval | MYO3A | 53904 | rs16926523 | 4.00E-06 | PV |
23251661 | Obesity-related traits | MYO3A | 53904 | rs12764197 | 6.00E-06 | PV |
23251661 | Obesity-related traits | MYO3A | 53904 | rs2096176 | 5.00E-06 | PV |
21130836 | Information processing speed | MYRIP | 25924 | rs9985399 | 9.00E-06 | PV |
17903308 | Sleep duration | MYRIP | 25924 | rs6599077 | 1.00E-07 | PV |
24026423 | Mean platelet volume | NFE2 | 4778 | rs10506328 | 2.00E-09 | PV |
23934736 | Metabolite levels (X-11787) | NRG1 | 3084 | rs1487141 | 3.00E-06 | PV |
23870195 | Coronary artery calcification | NRG1 | 3084 | rs1462872 | 9.00E-06 | PV |
23408906 | Thyroid hormone levels | NRG1 | 3084 | rs7825175 | 3.00E-09 | PV |
22267200 | Thyroid cancer | NRG1 | 3084 | rs2439302 | 2.00E-09 | PV |
21546767 | Dialysis-related mortality | NRG1 | 3084 | rs2439312 | 7.00E-06 | PV |
19196962 | Hirschsprung's disease | NRG1 | 3084 | rs16879552 | 2.00E-08 | PV |
17903296 | Hip geometry | NRG1 | 3084 | rs10503887 | 2.00E-07 | PV |
21943158 | Cardiovascular disease risk factors | OASL | 8638 | rs3213545 | 4.00E-15 | PV |
20581827 | Type 2 diabetes | OASL | 8638 | rs7957197 | 2.00E-08 | PV |
22699663 | Periodontal microbiota | OTOF | 9381 | rs1011108 | 2.00E-06 | PV |
23128233 | Inflammatory bowel disease | PARK7 | 11315 | rs35675666 | 1.00E-15 | PV |
21658281 | Sudden cardiac arrest | PARP4 | 143 | rs9581094 | 7.00E-07 | PV |
23535033 | Alzheimer's disease (cognitive decline) | PARVB | 29780 | rs75617873 | 5.00E-07 | PV |
22719876 | Nonalcoholic fatty liver disease | PARVB | 29780 | rs2073080 | 8.00E-07 | PV |
19060906 | HDL cholesterol | PCIF1 | 63935 | rs7679 | 4.00E-09 | PV |
24068947 | Relative hand skill in reading disability | PCSK6 | 5046 | rs7182874 | 9.00E-09 | PV |
21051773 | Handedness in dyslexia | PCSK6 | 5046 | rs11855415 | 2.00E-08 | PV |
22286219 | Metabolite levels | PHF23 | 79142 | rs117616209 | 3.00E-14 | PV |
23666240 | Testicular germ cell tumor | PITX1 | 5307 | rs3805663 | 2.00E-08 | PV |
24097068 | Cholesterol, total | PPARA | 5465 | rs4253772 | 1.00E-08 | PV |
22446961 | Kawasaki disease | PPM1L | 151742 | rs9290065 | 9.00E-06 | PV |
22387998 | Duodenal ulcer | PSCA | 8000 | rs2294008 | 2.00E-33 | PV |
22959728 | Amyotrophic lateral sclerosis (age of onset) | PTPRF | 5792 | rs2819332 | 5.00E-06 | PV |
23974872 | Schizophrenia | QPCT | 25797 | rs2373000 | 7.00E-09 | PV |
20189936 | Height | QSOX2 | 169714 | rs12338076 | 2.00E-08 | PV |
22542470 | Immune response to smallpox vaccine (IL-6) | RAB10 | 10890 | rs13388915 | 8.00E-06 | PV |
22610502 | Immune reponse to smallpox (secreted IL-1beta) | RAB6B | 51560 | rs9835973 | 7.00E-08 | PV |
20418489 | Type 2 diabetes | RBMS1 | 5937 | rs7593730 | 4.00E-08 | PV |
24026423 | Platelet counts | RCL1 | 10171 | rs423955 | 1.00E-09 | PV |
23263863 | Mean corpuscular hemoglobin | RCL1 | 10171 | rs10815094 | 5.00E-06 | PV |
23263863 | Mean corpuscular volume | RCL1 | 10171 | rs2236496 | 2.00E-07 | PV |
23263863 | Platelet counts | RCL1 | 10171 | rs457287 | 1.00E-06 | PV |
22139419 | Platelet counts | RCL1 | 10171 | rs13300663 | 1.00E-29 | PV |
19862010 | Mean corpuscular hemoglobin | RCL1 | 10171 | rs10758658 | 2.00E-14 | PV |
23028342 | Type 1 diabetes nephropathy | RNF10 | 9921 | rs614226 | 2.00E-06 | PV |
20686608 | Pancreatic cancer | RNF43 | 54894 | rs2257205 | 8.00E-06 | PV |
22267201 | Menopause (age at onset) | RNF44 | 22838 | rs890835 | 6.00E-06 | PV |
20881960 | Height | RYBP | 23429 | rs9863706 | 4.00E-13 | PV |
21833088 | Multiple sclerosis | SAE1 | 10055 | rs307896 | 5.00E-07 | PV |
23144326 | Chronic obstructive pulmonary disease-related biomarkers | SFTPD | 6441 | rs7078012 | 5.00E-09 | PV |
23563607 | Obesity | SH2B1 | 25970 | rs7498665 | 3.00E-13 | PV |
20935630 | Body mass index | SH2B1 | 25970 | rs7359397 | 2.00E-20 | PV |
22951594 | Breast cancer | SIAH2 | 6478 | rs6788895 | 9.00E-08 | PV |
23817569 | Self-reported allergy | SMAD3 | 4088 | rs17228058 | 1.00E-08 | PV |
23291589 | Corneal structure | SMAD3 | 4088 | rs12913547 | 5.00E-10 | PV |
23128233 | Inflammatory bowel disease | SMAD3 | 4088 | rs17293632 | 6.00E-16 | PV |
20860503 | Asthma | SMAD3 | 4088 | rs744910 | 4.00E-09 | PV |
17634449 | Coronary heart disease | SMAD3 | 4088 | rs17228212 | 2.00E-07 | PV |
23251661 | Obesity-related traits | SP110 | 3431 | rs13010639 | 6.00E-06 | PV |
18937294 | Attention deficit hyperactivity disorder (time to onset) | SULF2 | 55959 | rs4810685 | 7.00E-06 | PV |
24097068 | HDL cholesterol | TBL2 | 26608 | rs17145738 | 5.00E-13 | PV |
23505323 | Hypertriglyceridemia | TBL2 | 26608 | rs2286276 | 2.00E-06 | PV |
23251661 | Obesity-related traits | TCFL5 | 10732 | rs17854409 | 9.00E-06 | PV |
21076409 | Ventricular conduction | TKT | 7086 | rs4687718 | 6.00E-09 | PV |
23652523 | Helicobacter pylori serologic status | TLR10 | 81793 | rs10004195 | 1.00E-18 | PV |
23936387 | Celiac disease | TPTE | 7179 | rs10439884 | 2.00E-06 | PV |
21452313 | Rheumatoid arthritis | TRHDE | 29953 | rs12831974 | 6.00E-06 | PV |
21654844 | Multiple sclerosis | TRIM2 | 23321 | rs12644284 | 4.00E-06 | PV |
21886157 | Metabolic traits | TRIM4 | 89122 | rs17277546 | 9.00E-40 | PV |
19721433 | Response to antipsychotic treatment | TRPM1 | 4308 | rs17815774 | 3.00E-06 | PV |
23793025 | Migraine | TRPM8 | 79054 | rs6741751 | 9.00E-14 | PV |
22683712 | Migraine | TRPM8 | 79054 | rs10166942 | 1.00E-12 | PV |
23817569 | Self-reported allergy | TTC6 | 319089 | rs1998359 | 5.00E-08 | PV |
21810271 | vWF and FVIII levels | VAV2 | 7410 | rs12344583 | 8.00E-06 | PV |
20598377 | Multiple sclerosis | VAV2 | 7410 | rs3780792 | 1.00E-06 | PV |
22960999 | Esophageal cancer (squamous cell) | XBP1 | 7494 | rs2239815 | 4.00E-15 | PV |
22610502 | Immune reponse to smallpox (secreted IL-1beta) | XKR4 | 114786 | rs12542677 | 2.00E-07 | PV |
22719876 | Nonalcoholic fatty liver disease | YIPF1 | 54432 | rs11206226 | 5.00E-06 | PV |
20881960 | Height | ZMIZ1 | 57178 | rs7916441 | 6.00E-10 | PV |
23563607 | Height | ZMIZ1 | 57178 | rs780151 | 2.00E-09 | PV |
23535729 | Breast cancer | ZMIZ1 | 57178 | rs704010 | 7.00E-22 | PV |
23453885 | Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) | ZMIZ1 | 57178 | rs703970 | 5.00E-06 | PV |
22482804 | Crohn's disease and psoriasis | ZMIZ1 | 57178 | rs1250544 | 7.00E-14 | PV |
22190364 | Multiple sclerosis | ZMIZ1 | 57178 | rs1250542 | 4.00E-07 | PV |
21833088 | Multiple sclerosis | ZMIZ1 | 57178 | rs1250550 | 6.00E-09 | PV |
20526339 | Vitiligo | ZMIZ1 | 57178 | rs11593576 | 8.00E-07 | PV |
20190752 | Celiac disease | ZMIZ1 | 57178 | rs1250552 | 9.00E-10 | PV |
19525953 | Multiple sclerosis | ZMIZ1 | 57178 | rs1250540 | 2.00E-06 | PV |