RNAi screen analysis of viral host genes
Reference | Disease | Gene | SNP ID | SNP | p-value | Virus |
---|---|---|---|---|---|---|
Reference | Disease | Gene | SNP ID | SNP | p-value | Virus |
23251661 | Obesity-related traits | AATK | 9625 | rs7220048 | 9.00E-06 | IAV |
24024966 | Periodontitis (CDC/AAP) | ACTN2 | 88 | rs12048046 | 3.00E-06 | IAV |
22990015 | Stroke (pediatric) | ADAMTS2 | 9509 | rs469568 | 8.00E-06 | IAV |
22589738 | Visceral adipose tissue adjusted for BMI | ADAMTS2 | 9509 | rs901254 | 9.00E-06 | IAV |
18937294 | Attention deficit hyperactivity disorder (time to onset) | ADAMTS2 | 9509 | rs10039254 | 8.00E-06 | IAV |
23599027 | Menarche (age at onset) | AKT3 | 10000 | rs320320 | 5.00E-06 | IAV |
20031603 | RR interval (heart rate) | AKT3 | 10000 | rs4132509 | 2.00E-06 | IAV |
21833088 | Multiple sclerosis | ALPK2 | 115701 | rs12456021 | 4.00E-06 | IAV |
22139419 | Mean platelet volume | AP2B1 | 163 | rs16971217 | 4.00E-12 | IAV |
22566498 | Response to angiotensin II receptor blocker therapy | APBB1IP | 54518 | rs2992257 | 3.00E-07 | IAV |
22228203 | Inflammatory biomarkers | APBB1IP | 54518 | rs786870 | 5.00E-07 | IAV |
23989729 | Infantile hypertrophic pyloric stenosis | APOA1 | 335 | rs12721025 | 2.00E-10 | IAV |
24023260 | Lipid traits | APOA5 | 116519 | rs662799 | 6.00E-24 | IAV |
22286219 | Lipid metabolism phenotypes | APOA5 | 116519 | rs651821 | 8.00E-20 | IAV |
21782286 | Aging (time to event) | ATCAY | 85300 | rs10412199 | 3.00E-06 | IAV |
23128233 | Crohn's disease | ATG16L1 | 55054 | rs12994997 | 4.00E-70 | IAV |
18587394 | Crohn's disease | ATG16L1 | 55054 | rs3828309 | 2.00E-32 | IAV |
17554300 | Crohn's disease | ATG16L1 | 55054 | rs10210302 | 5.00E-14 | IAV |
20038947 | Major depressive disorder (broad) | ATP6V1B2 | 526 | rs1106634 | 7.00E-07 | IAV |
22542470 | Immune response to smallpox vaccine (IL-6) | BCR | 613 | rs9608102 | 8.00E-06 | IAV |
18391951 | Height | BCR | 613 | rs5751614 | 6.00E-06 | IAV |
20732626 | Attention deficit hyperactivity disorder | BMPR1B | 658 | rs1859156 | 2.00E-06 | IAV |
23263486 | Urate levels | BMPR2 | 659 | rs12468226 | 3.00E-06 | IAV |
19010793 | Multiple sclerosis (severity) | C1GALT1 | 56913 | rs10259085 | 4.00E-06 | IAV |
23535033 | Alzheimer's disease (cognitive decline) | CACNA1G | 8913 | rs117964204 | 1.00E-09 | IAV |
21926972 | Bipolar disorder | CACNB3 | 784 | rs2070615 | 1.00E-06 | IAV |
23251661 | Obesity-related traits | CADM1 | 23705 | rs220836 | 6.00E-06 | IAV |
23563607 | Obesity | CADM2 | 253559 | rs13078807 | 3.00E-11 | IAV |
22589738 | Visceral fat | CADM2 | 253559 | rs13323436 | 3.00E-06 | IAV |
19165232 | Panic disorder | CALCOCO1 | 57658 | rs941184 | 3.00E-07 | IAV |
21546767 | Dialysis-related mortality | CALM2 | 805 | rs815815 | 7.00E-07 | IAV |
23989986 | Osteoarthritis (hip) | CAMK2B | 816 | rs3757837 | 8.00E-10 | IAV |
22399527 | Metabolic syndrome | CAMK2B | 816 | rs1127065 | 9.00E-11 | IAV |
21833088 | Multiple sclerosis | CD58 | 965 | rs1335532 | 3.00E-16 | IAV |
21471979 | Large B-cell lymphoma | CDC42BPB | 9578 | rs751837 | 3.00E-07 | IAV |
23958962 | Cocaine dependence | CDK1 | 983 | rs2456778 | 5.00E-06 | IAV |
23273568 | Systemic lupus erythematosus | CDKN1B | 1027 | rs34330 | 5.00E-12 | IAV |
18957941 | Personality dimensions | CLOCK | 9575 | rs6832769 | 2.00E-06 | IAV |
24162737 | Alzheimer's disease (late onset) | CLU | 1191 | rs9331896 | 3.00E-25 | IAV |
21460841 | Alzheimer's disease (late onset) | CLU | 1191 | rs1532278 | 8.00E-08 | IAV |
19734902 | Alzheimer's disease | CLU | 1191 | rs11136000 | 9.00E-10 | IAV |
23049088 | Myopia (pathological) | CNTN5 | 53942 | rs12803066 | 4.00E-06 | IAV |
22610502 | Immune reponse to smallpox (secreted IL-2) | CNTN5 | 53942 | rs11223581 | 9.00E-09 | IAV |
17903304 | Atrial fibrillation | CNTN5 | 53942 | rs10501920 | 9.00E-06 | IAV |
17903297 | Volumetric brain MRI | CNTN5 | 53942 | rs952700 | 6.00E-06 | IAV |
17903305 | Breast cancer | COL1A1 | 1277 | rs2075555 | 8.00E-08 | IAV |
23263863 | Platelet counts | COPZ1 | 22818 | rs4326844 | 5.00E-08 | IAV |
23535033 | Alzheimer's disease (cognitive decline) | CRADD | 8738 | rs61144803 | 5.00E-08 | IAV |
23273568 | Systemic lupus erythematosus | CREBL2 | 1389 | rs12822507 | 2.00E-08 | IAV |
22504419 | Head circumference (infant) | CRHR1 | 1394 | rs11655470 | 4.00E-06 | IAV |
19801982 | Bone mineral density (hip) | CRHR1 | 1394 | rs9303521 | 4.00E-06 | IAV |
21642993 | Esophageal cancer | CSNK1A1 | 1452 | rs10058728 | 5.00E-09 | IAV |
17903305 | Prostate cancer | CTDSPL | 10217 | rs9311171 | 2.00E-06 | IAV |
24025145 | Adverse response to chemotherapy in breast cancer (alopecia) (cyclophosphamide+doxorubicin+/-5FU) | CTH | 1491 | rs672203 | 2.00E-06 | IAV |
17903296 | Bone mineral density | CTNNBL1 | 56259 | rs4811196 | 1.00E-06 | IAV |
23535033 | Alzheimer's disease (cognitive decline) | CYCS | 54205 | rs1861525 | 2.00E-07 | IAV |
24001895 | Blood pressure | CYP17A1 | 1586 | rs3824755 | 1.00E-06 | IAV |
20010834 | Pulmonary function | DAAM2 | 23500 | rs2395730 | 8.00E-08 | IAV |
23934736 | Metabolite levels (Pyroglutamine) | DAP | 1611 | rs3756407 | 5.00E-06 | IAV |
23128233 | Inflammatory bowel disease | DAP | 1611 | rs2930047 | 1.00E-08 | IAV |
21297633 | Ulcerative colitis | DAP | 1611 | rs267939 | 6.00E-12 | IAV |
23535911 | Non-alcoholic fatty liver disease | DCLK1 | 9201 | rs2051090 | 7.00E-06 | IAV |
23251661 | Obesity-related traits | DCLK1 | 9201 | rs12428086 | 5.00E-06 | IAV |
21998595 | Height | DCLK1 | 9201 | rs6563210 | 7.00E-07 | IAV |
20548946 | Vertical cup-disc ratio | DCLK1 | 9201 | rs1926320 | 1.00E-08 | IAV |
24133439 | Social autistic-like traits | DCLK2 | 166614 | rs11947645 | 1.00E-06 | IAV |
24159190 | Serum dimethylarginine levels (asymmetric) | DDAH1 | 23576 | rs28489187 | 1.00E-40 | IAV |
24159190 | Serum dimethylarginine levels (symmetric) | DDAH1 | 23576 | rs1884139 | 1.00E-18 | IAV |
24068962 | Calcium levels | DGKD | 8527 | rs1550532 | 8.00E-11 | IAV |
20705733 | Calcium levels | DGKD | 8527 | rs838705 | 9.00E-06 | IAV |
22438815 | Parkinson's disease | DGKQ | 1609 | rs11248060 | 3.00E-12 | IAV |
23408906 | Thyroid hormone levels | DIO1 | 1733 | rs2235544 | 8.00E-32 | IAV |
23251661 | Obesity-related traits | DLG2 | 1740 | rs2116483 | 8.00E-06 | IAV |
22544364 | Wilms tumor | DLG2 | 1740 | rs790356 | 4.00E-15 | IAV |
22359512 | Phospholipid levels (plasma) | DLG2 | 1740 | rs17148090 | 4.00E-08 | IAV |
18464913 | Protein quantitative trait loci | DLG2 | 1740 | rs3885683 | 8.00E-06 | IAV |
17052657 | Parkinson's disease | DLG2 | 1740 | rs10501570 | 7.00E-06 | IAV |
22001757 | Liver enzyme levels (gamma-glutamyl transferase) | DLG5 | 9231 | rs754466 | 6.00E-10 | IAV |
22041458 | Response to antidepressant treatment | DMD | 1756 | rs16990008 | 2.00E-06 | IAV |
23583980 | Interstitial lung disease | DSP | 1832 | rs2076295 | 1.00E-19 | IAV |
22472876 | Major depressive disorder | DVL3 | 1857 | rs1969253 | 5.00E-06 | IAV |
23251661 | Obesity-related traits | DYNC1I1 | 1780 | rs1488515 | 1.00E-06 | IAV |
22610502 | Immune reponse to smallpox (secreted IL-10) | DYNC1I1 | 1780 | rs13231718 | 5.00E-09 | IAV |
21531791 | Glioma | EGFR | 1956 | rs11979158 | 7.00E-08 | IAV |
22327514 | Ewing sarcoma | EGR2 | 1959 | rs224278 | 4.00E-17 | IAV |
21685912 | Progressive supranuclear palsy | EIF2AK3 | 9451 | rs7571971 | 4.00E-13 | IAV |
20881960 | Height | EIF2AK3 | 9451 | rs11684404 | 1.00E-13 | IAV |
22969067 | Corneal curvature | EIF2AK4 | 440275 | rs2250402 | 6.00E-06 | IAV |
20800221 | Depression (quantitative trait) | EIF3F | 8665 | rs12420464 | 3.00E-06 | IAV |
23251661 | Obesity-related traits | ETS1 | 2113 | rs7117932 | 8.00E-06 | IAV |
20190752 | Celiac disease | ETS1 | 2113 | rs11221332 | 5.00E-16 | IAV |
20169177 | Systemic lupus erythematosus | ETS1 | 2113 | rs1128334 | 2.00E-11 | IAV |
23251661 | Obesity-related traits | EXT1 | 2131 | rs7459527 | 2.00E-06 | IAV |
19893584 | Height | EXT1 | 2131 | rs11989122 | 6.00E-06 | IAV |
23381943 | End-stage coagulation | F13A1 | 2162 | rs5985 | 3.00E-186 | IAV |
23381943 | End-stage coagulation | F13A1 | 2162 | rs3024321 | 8.00E-142 | IAV |
21116278 | MRI atrophy measures | F13A1 | 2162 | rs749005 | 3.00E-07 | IAV |
22139419 | Mean platelet volume | F2R | 2149 | rs2227831 | 1.00E-15 | IAV |
22001757 | Liver enzyme levels (alkaline phosphatase) | FADS2 | 9415 | rs174601 | 3.00E-09 | IAV |
21829377 | Phospholipid levels (plasma) | FADS2 | 9415 | rs1535 | 3.00E-63 | IAV |
21829377 | Phospholipid levels (plasma) | FADS2 | 9415 | rs174574 | 4.00E-55 | IAV |
20339536 | Response to statin therapy | FADS2 | 9415 | rs174583 | 3.00E-06 | IAV |
19060911 | Cholesterol, total | FADS2 | 9415 | rs174570 | 2.00E-10 | IAV |
20966902 | Height | FASTKD2 | 22868 | rs2277912 | 5.00E-06 | IAV |
23652523 | Helicobacter pylori serologic status | FCGR2A | 2212 | rs368433 | 2.00E-08 | IAV |
23128233 | Inflammatory bowel disease | FCGR2A | 2212 | rs1801274 | 2.00E-38 | IAV |
21784300 | Attention deficit hyperactivity disorder | FERMT3 | 83706 | rs12575642 | 1.00E-06 | IAV |
24143190 | Breast cancer | FGFR2 | 2263 | rs2981578 | 1.00E-12 | IAV |
23535729 | Breast cancer | FGFR2 | 2263 | rs2981579 | 2.00E-170 | IAV |
23354978 | Breast cancer | FGFR2 | 2263 | rs1078806 | 2.00E-06 | IAV |
22951594 | Breast cancer | FGFR2 | 2263 | rs3750817 | 8.00E-08 | IAV |
21263130 | Breast cancer | FGFR2 | 2263 | rs1219648 | 1.00E-30 | IAV |
21060860 | Breast cancer | FGFR2 | 2263 | rs2981575 | 1.00E-08 | IAV |
17529967 | Breast cancer | FGFR2 | 2263 | rs2981582 | 2.00E-76 | IAV |
23583979 | Heart rate | FNDC3B | 64778 | rs9647379 | 1.00E-09 | IAV |
23563607 | Height | FNDC3B | 64778 | rs4535251 | 4.00E-16 | IAV |
23291589 | Corneal structure | FNDC3B | 64778 | rs4894535 | 5.00E-12 | IAV |
24097068 | Cholesterol, total | FRK | 2444 | rs9488822 | 1.00E-09 | IAV |
23263486 | Urate levels | FRK | 2444 | rs1933737 | 7.00E-07 | IAV |
23696099 | Red blood cell traits | G6PD | 2539 | rs1050828 | 4.00E-13 | IAV |
23446634 | Red blood cell traits | G6PD | 2539 | rs762516 | 2.00E-16 | IAV |
18985386 | Parkinson's disease (familial) | GAK | 2580 | rs1564282 | 7.00E-07 | IAV |
20711177 | Parkinson's disease | GAK | 2580 | rs11248051 | 3.00E-09 | IAV |
23128233 | Ulcerative colitis | GNA12 | 2768 | rs798502 | 6.00E-17 | IAV |
20881960 | Height | GNA12 | 2768 | rs798489 | 2.00E-33 | IAV |
20189936 | Height | GNA12 | 2768 | rs798497 | 7.00E-07 | IAV |
19343178 | Height | GNA12 | 2768 | rs1182188 | 3.00E-09 | IAV |
22542470 | Immune response to smallpox vaccine (IL-6) | GOLGA3 | 2802 | rs12282 | 3.00E-07 | IAV |
21107309 | Working memory | GPR137B | 7107 | rs7520258 | 5.00E-07 | IAV |
23251661 | Obesity-related traits | GRK5 | 2869 | rs1397615 | 2.00E-06 | IAV |
22961080 | Type 2 diabetes | GRK5 | 2869 | rs10886471 | 7.00E-09 | IAV |
24097068 | HDL cholesterol | GSK3B | 2932 | rs6805251 | 1.00E-08 | IAV |
20694148 | Metabolic syndrome | HERPUD1 | 9709 | rs2217332 | 3.00E-06 | IAV |
22087292 | Femoral neck bone geometry | HK2 | 3099 | rs681900 | 3.00E-06 | IAV |
23417110 | Beta-2 microglubulin plasma levels | HLA-B | 3106 | rs2523608 | 9.00E-09 | IAV |
22139419 | Platelet counts | HLA-B | 3106 | rs3819299 | 9.00E-10 | IAV |
19525953 | Multiple sclerosis | HLA-F-AS1 | 285830 | rs2523393 | 1.00E-17 | IAV |
23704328 | Primary tooth development (number of teeth) | HMGA2 | 8091 | rs17101923 | 1.00E-10 | IAV |
23563607 | Height | HMGA2 | 8091 | rs1351394 | 7.00E-32 | IAV |
23202124 | Birth weight | HMGA2 | 8091 | rs1042725 | 1.00E-19 | IAV |
22885925 | Polycystic ovary syndrome | HMGA2 | 8091 | rs2272046 | 2.00E-21 | IAV |
22504417 | Brain structure | HMGA2 | 8091 | rs10784502 | 1.00E-12 | IAV |
21998595 | Height | HMGA2 | 8091 | rs7979673 | 7.00E-10 | IAV |
20397748 | Height | HMGA2 | 8091 | rs8756 | 4.00E-07 | IAV |
24097068 | Cholesterol, total | HMGCR | 3156 | rs12916 | 5.00E-74 | IAV |
21909109 | Metabolite levels | HMGCR | 3156 | rs12654264 | 1.00E-20 | IAV |
19197348 | Quantitative traits | HMGCR | 3156 | rs3846663 | 1.00E-06 | IAV |
19060911 | Cholesterol, total | HMGCR | 3156 | rs3846662 | 3.00E-19 | IAV |
21107309 | Reasoning | HUNK | 30811 | rs2833556 | 5.00E-07 | IAV |
21533024 | Soluble ICAM-1 | ICAM1 | 3383 | rs1799969 | 1.00E-120 | IAV |
23251661 | Obesity-related traits | IFI16 | 3428 | rs861318 | 1.00E-06 | IAV |
21383967 | Celiac disease and Rheumatoid arthritis | IFI16 | 3428 | rs1772408 | 8.00E-07 | IAV |
23251661 | Obesity-related traits | IFNGR2 | 3460 | rs2268241 | 5.00E-06 | IAV |
23128233 | Crohn's disease | IFNGR2 | 3460 | rs2284553 | 2.00E-16 | IAV |
22936669 | Crohn's disease | IFNGR2 | 3460 | rs2834215 | 3.00E-07 | IAV |
23740937 | Systemic lupus erythematosus and Systemic sclerosis | IKZF3 | 22806 | rs9303277 | 7.00E-06 | IAV |
19458352 | Primary biliary cirrhosis | IKZF3 | 22806 | rs907092 | 8.00E-06 | IAV |
24182552 | Inflammatory biomarkers | IL1F10 | 84639 | rs6743376 | 2.00E-26 | IAV |
18464913 | Protein quantitative trait loci | IL1F10 | 84639 | rs6761276 | 7.00E-06 | IAV |
20966902 | Waist circumference | IL1RAP | 3556 | rs9290936 | 4.00E-06 | IAV |
18385676 | Lung cancer | IL1RAP | 3556 | rs7626795 | 8.00E-06 | IAV |
23251661 | Obesity-related traits | IL1RN | 3557 | rs4252023 | 2.00E-06 | IAV |
23128233 | Inflammatory bowel disease | IL27 | 246778 | rs26528 | 1.00E-21 | IAV |
23472165 | Endometriosis | IL33 | 90865 | rs10975519 | 9.00E-07 | IAV |
23362303 | Oleic acid (18:1n-9) plasma levels | IL5RA | 3568 | rs334809 | 1.00E-06 | IAV |
22542470 | Immune response to smallpox vaccine (IL-6) | IL5RA | 3568 | rs3804795 | 1.00E-06 | IAV |
22359512 | Phospholipid levels (plasma) | ILKAP | 80895 | rs12472274 | 2.00E-08 | IAV |
23092984 | Bipolar disorder (mood-incongruent) | INPP4A | 3631 | rs12617721 | 7.00E-06 | IAV |
20010835 | Pulmonary function | INTS12 | 57117 | rs11727189 | 5.00E-17 | IAV |
22139419 | Platelet counts | IRF1 | 3659 | rs2070729 | 1.00E-10 | IAV |
22863734 | Orofacial clefts | IRF6 | 3664 | rs861020 | 3.00E-12 | IAV |
23314186 | Monocyte count | IRF8 | 3394 | rs424971 | 3.00E-16 | IAV |
21131588 | Chronic lymphocytic leukemia | IRF8 | 3394 | rs391525 | 3.00E-09 | IAV |
18587394 | Crohn's disease | ITLN1 | 55600 | rs2274910 | 1.00E-09 | IAV |
22139419 | Platelet counts | ITPK1 | 3705 | rs8006385 | 1.00E-10 | IAV |
17827064 | Amyotrophic lateral sclerosis | ITPR2 | 3709 | rs2306677 | 3.00E-06 | IAV |
23266558 | Crohn's disease | JAK2 | 3717 | rs2274471 | 5.00E-06 | IAV |
19287384 | Myeloproliferative neoplasms | JAK2 | 3717 | rs10974944 | 4.00E-20 | IAV |
22504418 | Intracranial volume | KANSL1 | 284058 | rs9303525 | 8.00E-15 | IAV |
19056611 | Type 2 diabetes | KCNJ11 | 3767 | rs5219 | 5.00E-07 | IAV |
18372903 | Type 2 diabetes | KCNJ11 | 3767 | rs5215 | 4.00E-07 | IAV |
20881960 | Height | KCNJ12 | 3768 | rs4640244 | 2.00E-08 | IAV |
21708048 | Obesity | KCNMA1 | 3778 | rs2116830 | 3.00E-10 | IAV |
21102462 | Menarche (age at onset) | KDM3B | 51780 | rs757647 | 5.00E-08 | IAV |
24024966 | Periodontitis (CDC/AAP) | KDM4B | 23030 | rs11673509 | 6.00E-06 | IAV |
19451621 | Amyotrophic lateral sclerosis | KIFAP3 | 22920 | rs1541160 | 2.00E-08 | IAV |
23472165 | Endometriosis | KSR2 | 283455 | rs10431397 | 7.00E-06 | IAV |
22589738 | Visceral adipose tissue adjusted for BMI | KSR2 | 283455 | rs4304868 | 8.00E-06 | IAV |
19260141 | Biochemical measures | KSR2 | 283455 | rs10444502 | 6.00E-06 | IAV |
19260141 | Biochemical measures | KSR2 | 283455 | rs4767631 | 6.00E-07 | IAV |
20972440 | Colorectal cancer | LAMA5 | 3911 | rs4925386 | 2.00E-10 | IAV |
23844046 | C-reactive protein | LEPR | 3953 | rs10889569 | 9.00E-09 | IAV |
23563609 | Obesity (early onset extreme) | LEPR | 3953 | rs11208659 | 2.00E-09 | IAV |
22939635 | C-reactive protein | LEPR | 3953 | rs1805096 | 2.00E-09 | IAV |
20167575 | Soluble leptin receptor levels | LEPR | 3953 | rs1751492 | 6.00E-13 | IAV |
19567438 | C-reactive protein | LEPR | 3953 | rs6700896 | 3.00E-14 | IAV |
23408906 | Thyroid hormone levels | LHX3 | 8022 | rs7860634 | 2.00E-14 | IAV |
21606135 | Coronary heart disease | LIPA | 3988 | rs1412444 | 4.00E-08 | IAV |
24024966 | Periodontitis (CDC/AAP) | LRP1B | 53353 | rs72899866 | 5.00E-06 | IAV |
21102462 | Menarche (age at onset) | LRP1B | 53353 | rs12472911 | 2.00E-07 | IAV |
20932654 | Erectile dysfunction and prostate cancer treatment | LRP1B | 53353 | rs10210358 | 2.00E-06 | IAV |
20395239 | Optic disc size (disc) | LRP1B | 53353 | rs491391 | 3.00E-07 | IAV |
19367585 | Aging | LRP1B | 53353 | rs12474609 | 6.00E-09 | IAV |
23291589 | Corneal structure | LRRK1 | 79705 | rs930847 | 6.00E-19 | IAV |
22581228 | Fasting glucose-related traits (interaction with BMI) | MADD | 8567 | rs7944584 | 4.00E-12 | IAV |
21873549 | Proinsulin levels | MADD | 8567 | rs10501320 | 1.00E-88 | IAV |
21873549 | Proinsulin levels | MADD | 8567 | rs10838687 | 7.00E-12 | IAV |
23945395 | Type 2 diabetes | MAEA | 10296 | rs6815464 | 2.00E-07 | IAV |
23251661 | Obesity-related traits | MAEA | 10296 | rs13108904 | 2.00E-06 | IAV |
19668339 | Hippocampal atrophy | MAL2 | 114569 | rs1364705 | 9.00E-06 | IAV |
23563607 | Obesity | MAP2K5 | 5607 | rs8028313 | 6.00E-13 | IAV |
22344219 | Body mass index | MAP2K5 | 5607 | rs4776970 | 2.00E-09 | IAV |
21779176 | Restless legs syndrome | MAP2K5 | 5607 | rs12593813 | 1.00E-22 | IAV |
20935630 | Body mass index | MAP2K5 | 5607 | rs2241423 | 1.00E-18 | IAV |
21107309 | Reasoning | MAP3K9 | 4293 | rs17108533 | 1.00E-06 | IAV |
21833088 | Multiple sclerosis | MAPK1 | 5594 | rs2283792 | 5.00E-09 | IAV |
23572186 | Bone mineral density | MEF2C | 4208 | rs11951031 | 9.00E-09 | IAV |
23400010 | Thiazide-induced adverse metabolic effects in hypertensive patients | MEF2C | 4208 | rs17560407 | 5.00E-07 | IAV |
22139419 | Mean platelet volume | MEF2C | 4208 | rs4521516 | 2.00E-09 | IAV |
22139419 | Platelet counts | MEF2C | 4208 | rs700585 | 1.00E-09 | IAV |
17903302 | Tonometry | MEF2C | 4208 | rs770189 | 3.00E-06 | IAV |
22589738 | Visceral adipose tissue adjusted for BMI | MICA | 100507436 | rs12175489 | 2.00E-06 | IAV |
21653640 | Rheumatoid arthritis | MICA | 100507436 | rs1063635 | 1.00E-17 | IAV |
21499248 | Hepatocellular carcinoma | MICA | 100507436 | rs2596542 | 4.00E-13 | IAV |
20881960 | Height | MICA | 100507436 | rs2256183 | 8.00E-29 | IAV |
23534349 | PR interval | MICAL2 | 9645 | rs1994318 | 2.00E-06 | IAV |
22881374 | Alzheimer's disease (late onset) | MPZL1 | 9019 | rs4145462 | 1.00E-06 | IAV |
23824729 | Homocysteine levels | MTR | 4548 | rs2275565 | 2.00E-10 | IAV |
23551011 | Preeclampsia | MYCBP2 | 23077 | rs7322722 | 1.00E-06 | IAV |
20395239 | Optic disc size (rim) | MYH9 | 4627 | rs735854 | 9.00E-06 | IAV |
22675492 | Testosterone levels | MYOCD | 93649 | rs9905820 | 4.00E-06 | IAV |
23533358 | Addiction | NCK2 | 8440 | rs2377339 | 1.00E-11 | IAV |
23958962 | Cocaine dependence | NCOR2 | 9612 | rs150954431 | 5.00E-07 | IAV |
23648065 | Adverse response to chemotherapy (neutropenia/leucopenia) (all antimetabolite drugs) | NCOR2 | 9612 | rs12582168 | 9.00E-06 | IAV |
19734545 | Cognitive performance | NCOR2 | 9612 | rs12423712 | 7.00E-06 | IAV |
20935630 | Body mass index | NFE2L1 | 4779 | rs3764400 | 4.00E-07 | IAV |
23128233 | Ulcerative colitis | NFKB1 | 4790 | rs3774959 | 4.00E-12 | IAV |
22479419 | Schizophrenia (treatment refractory) | NFKB1 | 4790 | rs230529 | 2.00E-07 | IAV |
23028356 | Rheumatoid arthritis | NFKBIE | 4794 | rs2233434 | 1.00E-15 | IAV |
23563609 | Obesity (early onset extreme) | NINJ1 | 4814 | rs2275848 | 1.00E-06 | IAV |
23128233 | Crohn's disease | NOD2 | 64127 | rs2066847 | 6.00E-209 | IAV |
22412388 | Crohn's disease | NOD2 | 64127 | rs2076756 | 1.00E-37 | IAV |
18758464 | Inflammatory bowel disease | NOD2 | 64127 | rs5743289 | 4.00E-10 | IAV |
17554300 | Crohn's disease | NOD2 | 64127 | rs17221417 | 4.00E-11 | IAV |
23297363 | Tetralogy of Fallot | NRP1 | 8829 | rs2228638 | 2.00E-07 | IAV |
21909110 | Blood pressure | NT5C2 | 22978 | rs11191593 | 1.00E-15 | IAV |
23453885 | Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) | NT5C2 | 22978 | rs11191580 | 1.00E-08 | IAV |
23251661 | Obesity-related traits | NUP153 | 9972 | rs2274136 | 3.00E-06 | IAV |
18391951 | Height | NUP153 | 9972 | rs12199222 | 7.00E-07 | IAV |
21623375 | Paget's disease | NUP205 | 23165 | rs4294134 | 8.00E-10 | IAV |
23934736 | Metabolite levels (Dihydroxy docosatrienoic acid) | NUP98 | 4928 | rs685782 | 7.00E-06 | IAV |
21943158 | Cardiovascular disease risk factors | OASL | 8638 | rs3213545 | 4.00E-15 | IAV |
20581827 | Type 2 diabetes | OASL | 8638 | rs7957197 | 2.00E-08 | IAV |
23704328 | Primary tooth development (number of teeth) | OPN1SW | 611 | rs1799922 | 4.00E-09 | IAV |
22747683 | Breast size | OSBPL6 | 114880 | rs34479159 | 6.00E-06 | IAV |
21116278 | Total ventricular volume | PAK2 | 5062 | rs2084385 | 5.00E-06 | IAV |
22456796 | Type 2 diabetes | PALM2 | 114299 | rs1327796 | 3.00E-06 | IAV |
23251661 | Obesity-related traits | PANK4 | 55229 | rs12073504 | 5.00E-06 | IAV |
20881960 | Height | PCCB | 5096 | rs9844666 | 4.00E-09 | IAV |
23251661 | Obesity-related traits | PCF11 | 51585 | rs1943345 | 7.00E-06 | IAV |
21149283 | Iron status biomarkers | PCSK7 | 9159 | rs236918 | 1.00E-27 | IAV |
22144915 | Corneal astigmatism | PDGFRA | 5156 | rs7677751 | 8.00E-09 | IAV |
23921680 | Allergic dermatitis (nickel) | PELI1 | 57162 | rs6733160 | 7.00E-06 | IAV |
21221998 | Kawasaki disease | PELI1 | 57162 | rs7604693 | 2.00E-06 | IAV |
24105470 | Adiponectin levels | PEPD | 5184 | rs889140 | 4.00E-12 | IAV |
24097068 | HDL cholesterol | PEPD | 5184 | rs731839 | 3.00E-09 | IAV |
22581228 | Fasting insulin-related traits (interaction with BMI) | PEPD | 5184 | rs8182584 | 9.00E-08 | IAV |
22479202 | Adiponectin levels | PEPD | 5184 | rs4805885 | 2.00E-08 | IAV |
22158537 | Type 2 diabetes | PEPD | 5184 | rs3786897 | 1.00E-08 | IAV |
23817569 | Self-reported allergy | PEX14 | 5195 | rs2056417 | 4.00E-07 | IAV |
23535733 | Breast cancer | PEX14 | 5195 | rs616488 | 1.00E-08 | IAV |
20395239 | Optic disc size (rim) | PEX14 | 5195 | rs12741973 | 7.00E-06 | IAV |
23222517 | Red blood cell traits | PIEZO1 | 9780 | rs10445033 | 2.00E-22 | IAV |
22286219 | Lipid metabolism phenotypes | PLTP | 5360 | rs6065904 | 2.00E-31 | IAV |
23049088 | Myopia (pathological) | PML | 5371 | rs8039584 | 5.00E-08 | IAV |
21623375 | Paget's disease | PML | 5371 | rs5742915 | 2.00E-14 | IAV |
22634755 | Colorectal cancer | POLD3 | 10714 | rs3824999 | 4.00E-10 | IAV |
22889924 | Tourette syndrome | POLR3B | 55703 | rs6539267 | 6.00E-06 | IAV |
24097068 | Cholesterol, total | PPARA | 5465 | rs4253772 | 1.00E-08 | IAV |
23453885 | Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) | PPP2R2B | 5521 | rs609412 | 2.00E-06 | IAV |
19581569 | Alcohol dependence | PPP2R2B | 5521 | rs1864982 | 3.00E-06 | IAV |
20663923 | Autism | PPP2R5C | 5527 | rs7142002 | 3.00E-06 | IAV |
23263486 | Urate levels | PRKAG2 | 51422 | rs10480300 | 4.00E-09 | IAV |
21305692 | Bipolar disorder (age of onset and psychomotor symptoms) | PRKAG2 | 51422 | rs7795096 | 2.00E-06 | IAV |
20383146 | Chronic kidney disease | PRKAG2 | 51422 | rs7805747 | 4.00E-12 | IAV |
19862010 | Hematocrit | PRKAG2 | 51422 | rs10224002 | 6.00E-15 | IAV |
23870195 | Coronary artery calcification | PRKCA | 5578 | rs11651708 | 3.00E-06 | IAV |
23726511 | Post-traumatic stress disorder (asjusted for relatedness) | PRKCA | 5578 | rs7207499 | 5.00E-06 | IAV |
22021425 | Height | PRKCA | 5578 | rs3889237 | 3.00E-08 | IAV |
21076409 | Ventricular conduction | PRKCA | 5578 | rs9912468 | 1.00E-08 | IAV |
23472185 | Multiple sclerosis (OCB status) | PRKRA | 8575 | rs9283487 | 3.00E-07 | IAV |
23092984 | Bipolar disorder (mood-incongruent) | PRSS35 | 167681 | rs1171113 | 1.00E-07 | IAV |
22412388 | Crohn's disease | PSMB10 | 5699 | rs11574514 | 2.00E-07 | IAV |
19820697 | Hematological parameters | PTPN11 | 5781 | rs11066301 | 8.00E-12 | IAV |
21546767 | Dialysis-related mortality | PTPRM | 5797 | rs8098064 | 4.00E-06 | IAV |
21546767 | Dialysis-related mortality | PTPRM | 5797 | rs7243299 | 8.00E-06 | IAV |
23251661 | Obesity-related traits | RAB17 | 64284 | rs2292873 | 8.00E-06 | IAV |
22610502 | Immune reponse to smallpox (secreted IL-1beta) | RAB6B | 51560 | rs9835973 | 7.00E-08 | IAV |
23251661 | Obesity-related traits | RBBP6 | 5930 | rs7195386 | 9.00E-06 | IAV |
24097068 | HDL cholesterol | RBM5 | 10181 | rs2013208 | 9.00E-12 | IAV |
19196962 | Hirschsprung's disease | RET | 5979 | rs2742234 | 4.00E-18 | IAV |
22843503 | Resistin levels | RETN | 56729 | rs3745367 | 3.00E-06 | IAV |
20395239 | Optic disc size (cup) | RFTN1 | 23180 | rs690037 | 2.00E-07 | IAV |
20018961 | Leprosy | RIPK2 | 8767 | rs42490 | 1.00E-16 | IAV |
23412934 | Multiple sclerosis | RNASEL | 6041 | rs533259 | 6.00E-09 | IAV |
23144326 | Chronic obstructive pulmonary disease-related biomarkers | RNF150 | 57484 | rs10007052 | 1.00E-07 | IAV |
22267201 | Menopause (age at onset) | RNF44 | 22838 | rs890835 | 6.00E-06 | IAV |
22589738 | Visceral adipose tissue/subcutaneous adipose tissue ratio | RPS14 | 6208 | rs13177918 | 8.00E-06 | IAV |
23259602 | Dental caries | RPS6KA2 | 6196 | rs635808 | 1.00E-07 | IAV |
22019778 | Leprosy | RPS6KA4 | 8986 | rs538147 | 7.00E-06 | IAV |
22504420 | Bone mineral density | RPS6KA5 | 9252 | rs1286083 | 2.00E-15 | IAV |
23563607 | Obesity | RPTOR | 57521 | rs7503807 | 2.00E-08 | IAV |
23551011 | Preeclampsia | RUNX1 | 861 | rs9976946 | 5.00E-06 | IAV |
22542470 | Immune response to smallpox vaccine (IL-6) | RUNX1 | 861 | rs2834655 | 5.00E-07 | IAV |
21829377 | Phospholipid levels (plasma) | RUNX1 | 861 | rs9983044 | 2.00E-07 | IAV |
21642993 | Esophageal cancer | RUNX1 | 861 | rs2014300 | 8.00E-22 | IAV |
21368711 | Personality dimensions | RXRG | 6258 | rs285480 | 4.00E-07 | IAV |
21102462 | Menarche (age at onset) | RXRG | 6258 | rs466639 | 1.00E-13 | IAV |
19754311 | AIDS | RXRG | 6258 | rs10800098 | 4.00E-06 | IAV |
20881960 | Height | RYBP | 23429 | rs9863706 | 4.00E-13 | IAV |
21833088 | Multiple sclerosis | SAE1 | 10055 | rs307896 | 5.00E-07 | IAV |
22719876 | Nonalcoholic fatty liver disease | SAMM50 | 25813 | rs2143571 | 6.00E-07 | IAV |
20585324 | Conduct disorder (symptom count) | SELPLG | 6404 | rs8179116 | 3.00E-06 | IAV |
22990020 | Plasminogen activator inhibitor type 1 levels (PAI-1) | SERPINE1 | 5054 | rs2227631 | 3.00E-24 | IAV |
23300278 | Type 2 diabetes | SGCG | 6445 | rs9552911 | 2.00E-08 | IAV |
23192594 | Body mass index (interaction) | SGK1 | 6446 | rs1763500 | 2.00E-06 | IAV |
22610502 | Immune reponse to smallpox (secreted IFN-alpha) | SGK1 | 6446 | rs9493873 | 4.00E-07 | IAV |
22951594 | Breast cancer | SIAH2 | 6478 | rs6788895 | 9.00E-08 | IAV |
18193046 | Triglycerides | SIK3 | 23387 | rs2075292 | 5.00E-08 | IAV |
20139978 | mean corpuscular hemoglobin concentration | SLC12A7 | 10723 | rs4580814 | 5.00E-10 | IAV |
22581228 | Fasting glucose-related traits (interaction with BMI) | SLC2A2 | 6514 | rs11920090 | 8.00E-11 | IAV |
22001757 | Liver enzyme levels (gamma-glutamyl transferase) | SLC2A2 | 6514 | rs10513686 | 6.00E-11 | IAV |
23535729 | Breast cancer | SLC4A7 | 9497 | rs4973768 | 2.00E-30 | IAV |
22589738 | Subcutaneous adipose tissue | SMAD6 | 4091 | rs11858577 | 9.00E-06 | IAV |
23266556 | Colorectal cancer | SMAD7 | 4092 | rs4939827 | 2.00E-10 | IAV |
23222517 | Red blood cell traits | SMOC1 | 64093 | rs11627546 | 1.00E-09 | IAV |
22482804 | Crohn's disease and psoriasis | SOCS1 | 8651 | rs4780355 | 1.00E-13 | IAV |
24162737 | Alzheimer's disease (late onset) | SORL1 | 6653 | rs11218343 | 1.00E-14 | IAV |
21216879 | Insulin-like growth factors | SPOCK2 | 9806 | rs1245541 | 5.00E-07 | IAV |
24097068 | HDL cholesterol | STAB1 | 23166 | rs13326165 | 9.00E-11 | IAV |
24025145 | Adverse response to chemotherapy in breast cancer (alopecia) | STAM2 | 10254 | rs16830728 | 3.00E-08 | IAV |
23722424 | Educational attainment | STK24 | 8428 | rs3783006 | 8.00E-08 | IAV |
22159054 | Alzheimer's disease | STK24 | 8428 | rs912330 | 4.00E-06 | IAV |
20834067 | Longevity | STK24 | 8428 | rs9517320 | 1.00E-06 | IAV |
19114657 | Blood pressure | STK39 | 27347 | rs6749447 | 2.00E-07 | IAV |
18937294 | Attention deficit hyperactivity disorder (time to onset) | SULF2 | 55959 | rs4810685 | 7.00E-06 | IAV |
23382691 | IgG glycosylation | SUV420H1 | 51111 | rs4930561 | 1.00E-08 | IAV |
19010793 | Normalized brain volume | SVIL | 6840 | rs1927457 | 8.00E-06 | IAV |
23222517 | Red blood cell traits | SYCE2 | 256126 | rs741702 | 8.00E-20 | IAV |
22456796 | Type 2 diabetes | SYK | 6850 | rs10993738 | 5.00E-06 | IAV |
21833088 | Multiple sclerosis | SYK | 6850 | rs290986 | 9.00E-07 | IAV |
23480133 | Vascular dementia | SYK | 6850 | rs290227 | 7.00E-11 | IAV |
24026423 | Mean platelet volume | TAOK1 | 57551 | rs9900280 | 1.00E-10 | IAV |
22139419 | Platelet counts | TAOK1 | 57551 | rs559972 | 3.00E-18 | IAV |
22699663 | Periodontal microbiota | TBC1D1 | 23216 | rs10010758 | 4.00E-06 | IAV |
23945395 | Type 2 diabetes | TCF7L2 | 6934 | rs7903146 | 2.00E-15 | IAV |
23535729 | Breast cancer | TCF7L2 | 6934 | rs7904519 | 3.00E-08 | IAV |
23544013 | Breast Cancer in BRCA1 mutation carriers | TCF7L2 | 6934 | rs11196174 | 8.00E-07 | IAV |
21347282 | Coronary heart disease | TCF7L2 | 6934 | rs7901695 | 1.00E-06 | IAV |
20081858 | Fasting glucose-related traits | TCF7L2 | 6934 | rs4506565 | 1.00E-08 | IAV |
20081857 | Two-hour glucose challenge | TCF7L2 | 6934 | rs12243326 | 1.00E-07 | IAV |
20383146 | Chronic kidney disease | TFDP2 | 7029 | rs347685 | 3.00E-11 | IAV |
23455636 | Age-related macular degeneration | TGFBR1 | 7046 | rs334353 | 3.00E-11 | IAV |
23535729 | Breast cancer | TGFBR2 | 7048 | rs12493607 | 2.00E-08 | IAV |
17903302 | Tonometry | TGFBR2 | 7048 | rs3773643 | 2.00E-07 | IAV |
22561518 | Vitiligo | TICAM1 | 148022 | rs6510827 | 9.00E-08 | IAV |
20852632 | Ovarian cancer | TIPARP | 25976 | rs2665390 | 3.00E-07 | IAV |
22267201 | Menopause (age at onset) | TLK1 | 9874 | rs10183486 | 2.00E-14 | IAV |
23652523 | Helicobacter pylori serologic status | TLR10 | 81793 | rs10004195 | 1.00E-18 | IAV |
23897914 | Bronchopulmonary dysplasia | TNK2 | 10188 | rs2278034 | 5.00E-06 | IAV |
23053960 | Systemic lupus erythematosus | TNPO3 | 23534 | rs12531711 | 6.00E-13 | IAV |
21750679 | Systemic sclerosis | TNPO3 | 23534 | rs10488631 | 4.00E-07 | IAV |
21946351 | Basal cell carcinoma | TP53 | 7157 | rs78378222 | 2.00E-20 | IAV |
23150908 | Alzheimer's disease | TREM2 | 54209 | rs75932628 | 2.00E-12 | IAV |
22939635 | C-reactive protein | TREM2 | 54209 | rs7748513 | 1.00E-10 | IAV |
22883433 | Schizophrenia | TRIM26 | 7726 | rs2523722 | 1.00E-16 | IAV |
21926974 | Schizophrenia | TRIM26 | 7726 | rs2021722 | 2.00E-12 | IAV |
20881960 | Height | TULP4 | 56995 | rs9456307 | 2.00E-09 | IAV |
21102463 | Crohn's disease | TYK2 | 7297 | rs12720356 | 1.00E-12 | IAV |
21829393 | Type 1 diabetes autoantibodies | TYK2 | 7297 | rs2304256 | 1.00E-10 | IAV |
20953190 | Psoriasis | TYK2 | 7297 | rs280519 | 4.00E-09 | IAV |
23471985 | Brain connectivity | UBE2A | 7319 | rs7879933 | 2.00E-10 | IAV |
22797727 | Renal function-related traits (BUN) | UNCX | 340260 | rs10275044 | 4.00E-09 | IAV |
21810271 | vWF and FVIII levels | VAV2 | 7410 | rs12344583 | 8.00E-06 | IAV |
20598377 | Multiple sclerosis | VAV2 | 7410 | rs3780792 | 1.00E-06 | IAV |
24097068 | Cholesterol, total | VLDLR | 7436 | rs3780181 | 7.00E-10 | IAV |
23870195 | Coronary artery calcification | WDR33 | 55339 | rs17015535 | 6.00E-06 | IAV |
24144296 | Axial length | WDR34 | 89891 | rs12380424 | 6.00E-06 | IAV |
20383146 | Chronic kidney disease | WDR37 | 22884 | rs10794720 | 1.00E-08 | IAV |
22808956 | Antineutrophil cytoplasmic antibody-associated vasculitis | WNT9B | 7484 | rs11079740 | 9.00E-06 | IAV |
22960999 | Esophageal cancer (squamous cell) | XBP1 | 7494 | rs2239815 | 4.00E-15 | IAV |
23726511 | Post-traumatic stress disorder (asjusted for relatedness) | ZMAT3 | 64393 | rs4955793 | 2.00E-06 | IAV |
23396134 | Refractive error | ZMAT4 | 79698 | rs7829127 | 4.00E-10 | IAV |
17903298 | Fasting plasma glucose | ZMAT4 | 79698 | rs2722425 | 2.00E-08 | IAV |
20881960 | Height | ZMIZ1 | 57178 | rs7916441 | 6.00E-10 | IAV |
23563607 | Height | ZMIZ1 | 57178 | rs780151 | 2.00E-09 | IAV |
23535729 | Breast cancer | ZMIZ1 | 57178 | rs704010 | 7.00E-22 | IAV |
23453885 | Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) | ZMIZ1 | 57178 | rs703970 | 5.00E-06 | IAV |
22482804 | Crohn's disease and psoriasis | ZMIZ1 | 57178 | rs1250544 | 7.00E-14 | IAV |
22190364 | Multiple sclerosis | ZMIZ1 | 57178 | rs1250542 | 4.00E-07 | IAV |
21833088 | Multiple sclerosis | ZMIZ1 | 57178 | rs1250550 | 6.00E-09 | IAV |
20526339 | Vitiligo | ZMIZ1 | 57178 | rs11593576 | 8.00E-07 | IAV |
20190752 | Celiac disease | ZMIZ1 | 57178 | rs1250552 | 9.00E-10 | IAV |
19525953 | Multiple sclerosis | ZMIZ1 | 57178 | rs1250540 | 2.00E-06 | IAV |