Welcome to Co-inhibitory Molecules

Such molecules are negative regulator of immune response and counterbalances stimulatory signals thus mentioning immune homeostasis and tolerance. Wide array of inhibitory molecules, which can be soluble or expressed on the surface of immune cells and various other tissue cells,regulates growth, priming, functional maturation, and differentiation of immune response. In an essence such signals influences outcome of diverse cellular functions namely feto-maternal tolerance, transplantation tolerance, exhaustion, antigen specific response, tumor evasion mechanisms, autoimmune conditions. Immunomodulatory effects of therapies targeting different co-inhibitory ligand or their receptors are undergoing clinical trials for multiple diseases.