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Record - 1 of 13   [TOP]
Compound IDNVIC0013
Compound Structure
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InhibitorAB00991123
PubChem ID 17483530
Drug Bank ID
ChemSpider ID 17026724
SMILESC1CC(=CC2=CC=CC=C21)S(=O)(=O)NC3=CC=C(C=C3)N4C=NN=N4
Molecular Weight (in g/mol)353.398
TargetReplication
Assay TypeHigh throughput screening assay
Assay Description10-point concentration response assay
Assay SourceEnamine Ltd. (Kiev, Ukraine)
Cell TypeVero cells
OutcomeInhibition of virus-induced cytopathic effect
IC50 (in nM)
EC50 (in nM)3900
H-bond Acceptor4
H-bond Donor1
No. of Rotatable Bond Count4
XLogP4.37
PSA97.63
Reference(s)https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3994909/
PubMed ID [Source Literature] 24735442
Curatorkanikatuteja@gmail.com

                  
Record - 2 of 13   [TOP]
Compound IDNVIC0014
Compound Structure
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InhibitorAB00992391
PubChem ID 8189728
Drug Bank ID
ChemSpider ID 6491411
SMILESC1=CC(=CC=C1NS(=O)(=O)C2=CC(=C(C=C2)F)F)N3C=NN=N3
Molecular Weight (in g/mol)337.305
TargetReplication
Assay TypeHigh throughput screening assay
Assay Description10-point concentration response assay
Assay SourceEnamine Ltd. (Kiev, Ukraine)
Cell TypeVero cells
OutcomeInhibition of virus-induced cytopathic effect
IC50 (in nM)
EC50 (in nM)11700
H-bond Acceptor6
H-bond Donor1
No. of Rotatable Bond Count4
XLogP2.78
PSA97.63
Reference(s)https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3994909/
PubMed ID [Source Literature] 24735442
Curatorkanikatuteja@gmail.com

                  
Record - 3 of 13   [TOP]
Compound IDNVIC0015
Compound Structure
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InhibitorAB00993210
PubChem ID 25672978
Drug Bank ID
ChemSpider ID 22443136
SMILESCN(C)S(=O)(=O)C1=CC2=C(C=C1)N(CC2)S(=O)(=O)C3=CC=CS3
Molecular Weight (in g/mol)372.483
TargetReplication
Assay TypeHigh throughput screening assay
Assay Description10-point concentration response assay
Assay SourceEnamine Ltd. (Kiev, Ukraine)
Cell TypeVero cells
OutcomeInhibition of virus-induced cytopathic effect
IC50 (in nM)
EC50 (in nM)7800
H-bond Acceptor7
H-bond Donor0
No. of Rotatable Bond Count4
XLogP1.71
PSA119.76
Reference(s)https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3994909/
PubMed ID [Source Literature] 24735442
Curatorkanikatuteja@gmail.com

                  
Record - 4 of 13   [TOP]
Compound IDNVIC0019
Compound Structure
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InhibitorRibavirin
PubChem ID 37542
Drug Bank IDDB00811
ChemSpider ID 34439
SMILESC1=NC(=NN1C2C(C(C(O2)CO)O)O)C(=O)N
Molecular Weight (in g/mol)244.207
TargetReplication
Assay TypeBSL4 HTS assay
Assay DescriptionHRP-chemiluminescent
Assay Source
Cell TypeVero cells
OutcomeVirus inhibition
IC50 (in nM)
EC50 (in nM)3356
H-bond Acceptor7
H-bond Donor4
No. of Rotatable Bond Count3
XLogP-3
PSA143.72
Reference(s)https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2653211/
PubMed ID [Source Literature] 18313148
Curatorkanikatuteja@gmail.com

                  
Record - 5 of 13   [TOP]
Compound IDNVIC0019
Compound Structure
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InhibitorRibavirin
PubChem ID 37542
Drug Bank IDDB00811
ChemSpider ID 34439
SMILESC1=NC(=NN1C2C(C(C(O2)CO)O)O)C(=O)N
Molecular Weight (in g/mol)244.207
TargetReplication
Assay TypeBSL2 HTS assay
Assay DescriptionFluorescent immunodetection
Assay Source
Cell TypeVero cells
OutcomeVirus inhibition
IC50 (in nM)
EC50 (in nM)6041
H-bond Acceptor7
H-bond Donor4
No. of Rotatable Bond Count3
XLogP-3
PSA143.72
Reference(s)https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2653211/
PubMed ID [Source Literature] 18313148
Curatorpriyankapaul008@gmail.com

                  
Record - 6 of 13   [TOP]
Compound IDNVIC0019
Compound Structure
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InhibitorRibavirin
PubChem ID 37542
Drug Bank IDDB00811
ChemSpider ID 34439
SMILESC1=NC(=NN1C2C(C(C(O2)CO)O)O)C(=O)N
Molecular Weight (in g/mol)244.207
TargetReplication
Assay TypeCPE reduction assay
Assay DescriptionCPE Assay
Assay Source
Cell TypeVero E6 cells
OutcomeInhibit replication
IC50 (in nM)
EC50 (in nM)
H-bond Acceptor7
H-bond Donor4
No. of Rotatable Bond Count3
XLogP-3
PSA143.72
Reference(s)https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1472238/
PubMed ID [Source Literature] 16641448
Curatorkanikatuteja@gmail.com

                  
Record - 7 of 13   [TOP]
Compound IDNVIC0020
Compound Structure
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InhibitorEICAR
PubChem ID 453180
Drug Bank ID
ChemSpider ID 399153
SMILESC#CC1=C(N=CN1C2C(C(C(O2)CO)O)O)C(=O)N
Molecular Weight (in g/mol)267.241
TargetReplication
Assay TypeCPE reduction assay
Assay DescriptionCPE Assay
Assay Source
Cell TypeVero E6 cells
OutcomeInhibit replication
IC50 (in nM)
EC50 (in nM)
H-bond Acceptor7
H-bond Donor5
No. of Rotatable Bond Count3
XLogP-1.8
PSA130.83
Reference(s)https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1472238/
PubMed ID [Source Literature] 16641448
Curatorkanikatuteja@gmail.com

                  
Record - 8 of 13   [TOP]
Compound IDNVIC0021
Compound Structure
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InhibitorPyrazofurin
PubChem ID 135413551
Drug Bank ID
ChemSpider ID 10570780
SMILESC(C1C(C(C(O1)C2=NNC(=C2O)C(=O)N)O)O)O
Molecular Weight (in g/mol)259.218
TargetReplication
Assay TypeCPE reduction assay
Assay DescriptionCPE Assay
Assay Source
Cell TypeVero E6 cells
OutcomeInhibit replication
IC50 (in nM)
EC50 (in nM)
H-bond Acceptor8
H-bond Donor6
No. of Rotatable Bond Count3
XLogP-1.6
PSA161.92
Reference(s)https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1472238/
PubMed ID [Source Literature] 16641448
Curatorkanikatuteja@gmail.com

                  
Record - 9 of 13   [TOP]
Compound IDNVIC0023
Compound Structure
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Inhibitor6-Azauridine
PubChem ID 5901
Drug Bank ID
ChemSpider ID 203593
SMILESC1=NN(C(=O)NC1=O)C2C(C(C(O2)CO)O)O
Molecular Weight (in g/mol)245.191
TargetReplication
Assay TypeCPE reduction assay
Assay DescriptionCPE Assay
Assay Source
Cell TypeVero E6 cells
OutcomeInhibit replication
IC50 (in nM)
EC50 (in nM)
H-bond Acceptor8
H-bond Donor4
No. of Rotatable Bond Count2
XLogP-1.9
PSA131.69
Reference(s)https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1472238/
PubMed ID [Source Literature] 16641448
Curatorkanikatuteja@gmail.com

                  
Record - 10 of 13   [TOP]
Compound IDNVIC0032
Compound Structure
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Inhibitor09167(2,2,2-trifluoro-N-[3-(N-naphthylcarbamoyl)(4
PubChem ID 4293368
Drug Bank ID
ChemSpider ID 3499535
SMILESC1CCC2=C(C1)C(=C(S2)NC(=O)C(F)(F)F)C(=O)NC3=CC=CC4=CC=CC=C43
Molecular Weight (in g/mol)418.432
TargetReplication
Assay TypeDose-dependent inhibition of LUC2AM
Assay Description
Assay SourceVitas-M Laboratory
Cell TypeHEK 293T cells
OutcomeAblated NiV-LUC2AM activity
IC50 (in nM)
EC50 (in nM)72.3
H-bond Acceptor8
H-bond Donor2
No. of Rotatable Bond Count6
XLogP6.53
PSA86.44
Reference(s)https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5100748/
PubMed ID [Source Literature] 24680955
Curatorkanikatuteja@gmail.com

                  
Record - 11 of 13   [TOP]
Compound IDNVIC0032
Compound Structure
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Inhibitor09167(2,2,2-trifluoro-N-[3-(N-naphthylcarbamoyl)(4
PubChem ID 4293368
Drug Bank ID
ChemSpider ID 3499535
SMILESC1CCC2=C(C1)C(=C(S2)NC(=O)C(F)(F)F)C(=O)NC3=CC=CC4=CC=CC=C43
Molecular Weight (in g/mol)418.432
TargetReplication
Assay TypeDose-dependent inhibition of GFP2AM
Assay Description
Assay SourceVitas-M Laboratory
Cell TypeHEK 293T cells
OutcomeAblated NiV-GFP2AM avtivity
IC50 (in nM)
EC50 (in nM)254
H-bond Acceptor8
H-bond Donor2
No. of Rotatable Bond Count6
XLogP6.53
PSA86.44
Reference(s)https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5100748/
PubMed ID [Source Literature] 24680955
Curatorkanikatuteja@gmail.com

                  
Record - 12 of 13   [TOP]
Compound IDNVIC0032
Compound Structure
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Inhibitor09167(2,2,2-trifluoro-N-[3-(N-naphthylcarbamoyl)(4
PubChem ID 4293368
Drug Bank ID
ChemSpider ID 3499535
SMILESC1CCC2=C(C1)C(=C(S2)NC(=O)C(F)(F)F)C(=O)NC3=CC=CC4=CC=CC=C43
Molecular Weight (in g/mol)418.432
TargetReplication
Assay TypeDose-dependent inhibition of NiV-MY-99
Assay Description
Assay SourceVitas-M Laboratory
Cell TypeHEK 293T cells
OutcomeAblated NiV-MY-99 activity
IC50 (in nM)
EC50 (in nM)28.9
H-bond Acceptor8
H-bond Donor2
No. of Rotatable Bond Count6
XLogP6.53
PSA86.44
Reference(s)https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5100748/
PubMed ID [Source Literature] 24680955
Curatorkanikatuteja@gmail.com

                  
Record - 13 of 13   [TOP]
Compound IDNVIC0097
Compound Structure
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Inhibitor25-hydroxycholesterol
PubChem ID 65094
Drug Bank IDDB04705
ChemSpider ID 58604
SMILESCC(CCCC(C)(C)O)C1CCC2C1(CCC3C2CC=C4C3(CCC(C4)O)C)C
Molecular Weight (in g/mol)402.663
TargetReplication
Assay TypePlaque assay
Assay DescriptionVirus titration
Assay SourceProduced within mammalian species
Cell TypeHeLa cells
OutcomeInhibition of replication
IC50 (in nM)1000
EC50 (in nM)
H-bond Acceptor2
H-bond Donor2
No. of Rotatable Bond Count5
XLogP8.55
PSA40.46
Reference(s)https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3698975/
PubMed ID [Source Literature] 23273844
Curatorkanikatuteja@gmail.com