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NVIK FDA Drugs Similarity

Similarity with FDA Approved Small Molecule Drugs


Table: List of NVI's molecules showing similarity with FDA approved small molecule drugs

NVI's Compound DrugBank ID Tanimoto coefficient Side effects [From DrugBank] Predicted Rat acute toxicity (mol/kg) [LD50 Value from DrugBank] 
NVIC0019

DB00811

0.2"Rivabirin and PEG-Interferon Alfa-2A dual therapy is associated" "with flu-like symptoms, depression, suicide, insomnia, irritability, relapse of drug abuse/overdose, hepatic decompensation in 2% of HIV co-infected patients and bacterial infections each occurring at a frequency of less than 1%. Ribavirin-induced anemia is a dose-dependent adverse effect where reduced hemoglobin levels can be seen within the first 1-2 weeks in therapy."1.9876
NVIC0027

DB00188

0.2"Cardiovascular safety pharmacology studies in monkeys show that lethal IV doses are associated with decreases in blood pressure, increases in heart rate, increases in contractility, and ultimately terminal hypotension. In monkeys, doses of 3.0 mg/m2 and greater (approximately twice the recommended clinical dose) resulted in progressive hypotension starting at 1 hour and progressing to death by 12 to 14 hours following drug administration."2.4537
NVIC0036

DB01103

0.2"Symptoms of overdose include seizures, hypotension, cardiac arrhythmias, and cardiovascular collapse."2.8888
NVIC0037

DB00283

0.2"Antihistamine overdosage reactions may vary from central nervous system depression to stimulation. In children, stimulation predominates initially in a syndrome which may include excitement, hallucinations, ataxia, incoordination, muscle twitching, athetosis, hyperthermia, cyanosis convulsions, tremors, and hyperreflexia followed by postictal depression and cardio-respiratory arrest. Convulsions in children may be preceded by mild depression. Dry mouth, fixed dilated pupils, flushing of the face, and fever are common. In adults, CNS depression, ranging from drowsiness to coma, is more common."2.945
NVIC0044

DB00608

0.2N/A2.9547
NVIC0044

DB01611

0.2"Symptoms of overdose include headache, drowsiness, visual disturbances, cardiovascular collapse, and convulsions, followed by sudden and early respiratory and cardiac arrest. The electrocardiogram may reveal atrial standstill, nodal rhythm, prolonged intraventricular conduction time, and progressive bradycardia leading to ventricular fibrillation and/or arrest."2.6348
NVIC0048

DB00608

0.2N/A2.9547
NVIC0048

DB01611

0.2"Symptoms of overdose include headache, drowsiness, visual disturbances, cardiovascular collapse, and convulsions, followed by sudden and early respiratory and cardiac arrest. The electrocardiogram may reveal atrial standstill, nodal rhythm, prolonged intraventricular conduction time, and progressive bradycardia leading to ventricular fibrillation and/or arrest."2.6348
NVIC0050

DB02513

0.2N/A2.2996
NVIC0052

DB01219

0.2"Symptoms which may occur in case of overdose include, but are not limited to, muscular weakness and alterations in the state of consciousness (e.g., lethargy, coma), vomiting, diarrhea, and crystalluria."2.539
NVIC0057

DB09237

0.2"If overdose should occur, vigilant cardiac and respiratory monitoring should be initiated. As with all calcium channel blockers, the risk of reflex tachycardia Frequent blood pressure measurements is required. Should hypotension occur, supportive measures including elevation of the extremities and administration of fluids should be initiated. Administration of vasopressors (such as phenylephrine) may be considered with attention to monitoring urine output. Intravenous calcium gluconate may reverse the effects of calcium entry blockade. As amlodipine is highly protein bound, hemodialysis is unlikely to be beneficial "N/A
NVIC0057

DB00381

0.2Gross overdosage could result in excessive peripheral vasodilatation and possibly reflex tachycardia. Marked and probably prolonged systemic hypotension up to an including shock with fatal outcome have been reported.2.5396
NVIC0058

DB00996

0.2"Symptoms of overdose include ataxia, labored breathing, ptosis, sedation, hypoactivity, and excitation."1.6472
NVIC0061

DB00401

0.2N/A2.6277
NVIC0061

DB09229

0.2"In repeated dose studies, some of the reported side effects included increased urinary volume, serum lipid, urea nitrogen, liver weight, decreased urinary osmotic pressure and hypertrophy of hepatocytes. Teratogenic studies showed a slight generation of fetal visceral abnormalities. Other toxicity studies showed no effects on fetal development, reproductive ability, genotoxic, allergenic, or oncogenic potential."N/A
NVIC0061

DB01115

0.2"Symptoms of overdose include dizziness, drowsiness, nausea, severe drop in blood pressure, slurred speech, and weakness."2.5425
NVIC0062

DB01058

0.2N/A2.0726
NVIC0063

DB01199

0.2N/A2.6331
NVIC0063

DB01336

0.2N/A2.7086
NVIC0063

DB00416

0.2"Excessive doses can be expected to produce enhanced pharmacological effects. Overdosage may increase the risk of histamine release and cardiovascular effects, especially hypotension."2.7013
NVIC0064

DB00661

0.2N/A3.4137
NVIC0066

DB00594

0.2The most likely signs and symptoms to be expected with overdosage are dehydration and electrolyte imbalance.2.5469
NVIC0069

DB00252

0.2"Symptoms of overdose include coma, difficulty in pronouncing words correctly, involuntary eye movement, lack of muscle coordination, low blood pressure, nausea, sluggishness, slurred speech, tremors, and vomiting."2.1567
NVIC0071

DB00091

0.2" In cases of overdose, forced emesis and gastric lavage are recommended 2 hours after administration. After the intervention, transient hepatotoxicity and nephrotoxicity are still observed. However, doses of up to 150 mg/kg are tolerated with minor clinical consequences. Serious intoxication has been reported in accidental overdosage in premature neonates. When overdose with cyclosporine is observed, it is important to consider that dialysis and charcoal hemoperfusion are not responsive techniques.Cyclosporine was shown to present a trend for the generation of lymphocytic lymphomas, pancreatic islet carcinomas and hepatocellular carcinomas. It was not shown to present mutagenic or genotoxic potential and to not have any effect on fertility."2.8788
NVIC0072

DB06689

0.2Overdosage can result in severe intramural necrosis of the esophagus. Complications resulting from such overdosage have resulted in death.1.5407
NVIC0072

DB00154

0.2N/A1.3991
NVIC0072

DB04224

0.2N/A1.3991
NVIC0072

DB00132

0.2N/A1.4499
NVIC0072

DB14104

0.2N/AN/A
NVIC0073

DB00925

0.2"Symptoms of overdose are largely the result of block of the sympathetic nervous system and of the circulating epinephrine. They may include postural hypotension resulting in dizziness or fainting, tachycardia, particularly postural, vomiting; lethargy, and shock."2.1163
NVIC0077

DB06410

0.2N/AN/A
NVIC0077

DB00153

0.2"Nausea, vomiting and diarrhea, weight loss, irritability, weakness, fatigue, lassitude, and headache."3.6931
NVIC0077

DB00136

0.2"Overdose evident in elevated blood calcium levels causing symptoms of anorexia, nausea and vomiting, polyuria, polydipsia, weakness, pruritus, and nervousness, potentially with irreversible calcification of soft tissue in the kidney and liver."5.1352
NVIC0077

DB00169

0.2"Hypercalcemia - Early symptoms of hypercalcemia, include nausea and vomiting, weakness, headache, somnolence, dry mouth, constipation, metallic taste, muscle pain and bone pain. Late symptoms and signs of hypercalcemia, include polyuria, polydipsia, anorexia, weight loss, nocturia, conjunctivitis, pancreatitis, photophobia, rhinorrhea, pruritis, hyperthermia, decreased libido, elevated BUN, albuminuria, hypercholesterolemia, elevated ALT (SGPT) and AST (SGOT), ectopic calcification, nephrocalcinosis, hypertension and cardiac arrhythmias."3.931
NVIC0078

DB00675

0.2Signs observed at the highest doses following studies to determine LD50 in animals were respiratory difficulties and convulsions.1.9882
NVIC0078

DB00539

0.2N/A2.3467
NVIC0079

DB02638

0.2N/A2.9218
NVIC0079

DB00093

0.2N/AN/A
NVIC0079

DB00035

0.2"Desmopressin is associated with hyponatremia in case of overdose, which may require temporary or permanent discontinuation of the therapy depending on severity. The effects of hyponatremia include seizure, altered mental status (confusion, drowsiness or continuing headache), cardiac arrhythmias and worsening edema. Other signs of overdose may include oliguria and rapid weight gain due to fluid retention. In case of overdose, reduce the dose or frequency of drug administration, or discontinue use if appropriate. Assessment of serum sodium and initiation of appropriate medical treatment is recommended."2.7183
NVIC0081

DB00201

0.2N/A2.9741
NVIC0081

DB01412

0.2N/A2.7898
NVIC0081

DB00277

0.2"Symptoms of overdose include seizures, arrhythmias, and GI effects."2.7898
NVIC0081

DB01303

0.2"Symptoms of toxicity include abdominal pain (continuing or severe), confusion or change in behavior, convulsions (seizures), dark or bloody vomit, diarrhea, dizziness or lightheadedness, fast and/or irregular heartbeat, nervousness or restlessness (continuing), and trembling (continuing)."2.5809
NVIC0082

DB00146

0.2"Bone pain, constipation (especially in children or adolescents), diarrhea, drowsiness, dryness of mouth; headache (continuing), increased thirst, increase in frequency of urination, especially at night, or in amount of urine, irregular heartbeat, itching skin, loss of appetite, metallic taste, muscle pain, nausea or vomiting (especially in children or adolescents), unusual tiredness or weakness."4.1429
NVIC0082

DB01070

0.2Toxicity associated with dihydrotachysterol is similar to that seen with large doses of vitamin D.3.1244
NVIC0082

DB00136

0.2"Overdose evident in elevated blood calcium levels causing symptoms of anorexia, nausea and vomiting, polyuria, polydipsia, weakness, pruritus, and nervousness, potentially with irreversible calcification of soft tissue in the kidney and liver."5.1352
NVIC0082

DB00169

0.2"Hypercalcemia - Early symptoms of hypercalcemia, include nausea and vomiting, weakness, headache, somnolence, dry mouth, constipation, metallic taste, muscle pain and bone pain. Late symptoms and signs of hypercalcemia, include polyuria, polydipsia, anorexia, weight loss, nocturia, conjunctivitis, pancreatitis, photophobia, rhinorrhea, pruritis, hyperthermia, decreased libido, elevated BUN, albuminuria, hypercholesterolemia, elevated ALT (SGPT) and AST (SGOT), ectopic calcification, nephrocalcinosis, hypertension and cardiac arrhythmias."3.931
NVIC0083

DB00257

0.2"Symptoms of overdose include erythema, stinging, blistering, peeling, edema, pruritus, urticaria, burning, and general irritation of the skin, and cramps. As with all topical agents, skin sensitization may result. This drug poses no risk of acute intoxication, as it is unlikely to occur following a single vaginal or dermal application of an overdose (application over a large area under conditions favorable to absorption) or accidental oral ingestion. There is no specific antidote"2.7194
NVIC0084

DB00571

0.2"Symptoms of overdose include bradycardia, cardiac failure, hypotension, and brochospasm. "2.5625
NVIC0086

DB06616

0.2"Most common adverse reactions (incidence greater than 20%) are diarrhea, nausea, thrombocytopenia, vomiting, abdominal pain, rash, anemia, pyrexia, and fatigue. Because bosutinib is not an inhibitor of c-KIT or PDGF receptor, it has less hematologic toxicities."2.4201
NVIC0089

DB11256

0.2Overdose of levomefolic acid is unlikely to cause clinically significant adverse events.N/A
NVIC0089

DB00650

0.2 Excessive amounts of leucovorin may nullify the chemotherapeutic effect of folic acid antagonists.2.4254
NVIC0089

DB11596

0.2N/AN/A
NVIC0090

DB00157

0.2"No reports of overdose, however, high doses of NADH (10 mg a day or more) may cause jitteriness, anxiety, and insomnia."2.8642
NVIC0092

DB06784

0.2N/A1.8998
NVIC0092

DB11110

0.2The occurrence of overdose with magnesium citrate is very unlikely but some of the signs of the presence of overdose are diarrhea or severe stomach pain.N/A
NVIC0092

DB11154

0.2N/AN/A
NVIC0092

DB14507

0.2N/AN/A
NVIC0092

DB09154

0.2Overdose toxicity is mainly due to alkalosis as well as tetany or depressed heart function due to lack of free calcium N/A
NVIC0092

DB09275

0.2N/AN/A
NVIC0092

DB11093

0.2Patients taking more than 4g of calcium a day are at risk of hypercalcemia and metabolic alkalosis. Chronic intake of calcium supplements is associated with adverse gastrointestinal symptoms such as constipation and flatulence N/A
NVIC0092

DB14520

0.2"High concentrations of ferric iron from unstable and oversaturation of ferritin may lead to adverse events such as hypotension, nausea, vomiting, abdominal and lower back pain, peripheral edema and a metallic taste"N/A
NVIC0092

DB09125

0.2N/AN/A
NVIC0092

DB04272

0.2N/A1.7748
NVIC0094

DB00997

0.2N/A2.6644
NVIC0094

DB00445

0.2"bone marrow aplasia, grade 4 mucositis, and gastrointestinal bleeding"2.6644
NVIC0094

DB00694

0.2N/A3.2275
NVIC0094

DB01177

0.2N/A4.3474
NVIC0094

DB00385

0.2"The primary anticipated complications of overdosage associated with intravesical administration would be consistent with irritable bladder symptoms. Myelosuppression is possible if valrubicin is inadvertently administered systemically or if significant systemic exposure occurs following intravesical administration (e.g., in patients with bladder/rupture perforation)."2.8652
NVIC0094

DB06263

0.2"Myelosuppression, with the primary clinical manifestation of neutropenia and leucopenia, is the dose-limiting toxicity of this drug. In addition to this, mucositis, nausea, vomiting, and alopecia are frequent. Hepatopathy, observed with elevated bilirubin concentrations, occurs less frequently. Cardiotoxicity is a major adverse effect of the anthracycline antibiotics and may be acute or chronic; in the acute setting, electrocardiographic (ECG) abnormalities may be observed, demonstrating ST-T elevations and arrhythmias, however, chronic cardiotoxicity poses a serious risk that may be lethal due to the slow development of irreversible, cardiomyopathy. The occurrence of toxicity shows a significant interindividual variation, and for this reason, the pharmacokinetics and pharmacodynamics of anthracyclines have been heavily investigated in order to identify models that may be used in the clinical setting to prevent the development of serious toxicity, mainly leucopenia, and maximize tumor exposure. Interestingly, a recent study was done to further examine genetic predisposition neutropenia/amrubicin toxicity. It was determined that C3435T polymorphisms of the ABCB1 gene might be able to predict severe amrubicin-induced neutropenia.Secondary alcohol metabolites of earlier generation anthracyclines have been shown to lead to cardiac toxicity which is a major toxicity of conventional anthracyclines and thus limits the amount that can be delivered safely to patients. Clinical manifestations of toxicity observed on the acute and repeated administration of amrubicin in rats and dogs were dose-related and reversible including fecal changes (mucoid or bloody feces/diarrhea), body weight decreases, decreased food consumption, decreased activity, and alopecia. Similar findings were observed at doses of doxorubicin approximately one half those of amrubicin "N/A
NVIC0095

DB00173

0.2N/A2.4381
NVIC0097

DB00194

0.2"Acute massive overdosage by oral ingestion of the ophthalmic ointment has not occurred. However, the rapid deamination to arabinosylhypoxanthine should preclude any difficulty. Overdosage by ocular instillation is unlikely because any excess should be quickly expelled from the conjunctival sac."1.9715
NVIC0097

DB00640

0.2N/A1.9715
NVIC0097

DB00118

0.2Irritating to mucus membranes and upper respiratory tract. Can cause CNS depression.2.5758
NVIC0097

DB01073

0.2N/A2.2806