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Record - 1 of 3   [TOP]
Compound IDNVIC0021
Compound Structure
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InhibitorPyrazofurin
PubChem ID 135413551
Drug Bank ID
ChemSpider ID 10570780
SMILESC(C1C(C(C(O1)C2=NNC(=C2O)C(=O)N)O)O)O
Molecular Weight (in g/mol)259.218
TargetOrotidine 5?-monophosphate decarboxylase
Assay TypeDose-dependent inhibition of LUC2AM
Assay Description
Assay SourceToronto Research Chemicals
Cell TypeHEK 293T cells
OutcomeInhibition cellular of Pyrimidine biosynthesis
IC50 (in nM)
EC50 (in nM)432
H-bond Acceptor8
H-bond Donor6
No. of Rotatable Bond Count3
XLogP-1.6
PSA161.92
Reference(s)https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5100748/
PubMed ID [Source Literature] 24680955
Curatorkanikatuteja@gmail.com

                  
Record - 2 of 3   [TOP]
Compound IDNVIC0021
Compound Structure
DOWNLOAD:
InhibitorPyrazofurin
PubChem ID 135413551
Drug Bank ID
ChemSpider ID 10570780
SMILESC(C1C(C(C(O1)C2=NNC(=C2O)C(=O)N)O)O)O
Molecular Weight (in g/mol)259.218
TargetOrotidine 5?-monophosphate decarboxylase
Assay TypeDose-dependent inhibition of GFP2AM
Assay Description
Assay SourceToronto Research Chemicals
Cell TypeHEK 293T cells
OutcomeInhibition cellular of Pyrimidine biosynthesis
IC50 (in nM)
EC50 (in nM)281
H-bond Acceptor8
H-bond Donor6
No. of Rotatable Bond Count3
XLogP-1.6
PSA161.92
Reference(s)https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5100748/
PubMed ID [Source Literature] 24680955
Curatorkanikatuteja@gmail.com

                  
Record - 3 of 3   [TOP]
Compound IDNVIC0021
Compound Structure
DOWNLOAD:
InhibitorPyrazofurin
PubChem ID 135413551
Drug Bank ID
ChemSpider ID 10570780
SMILESC(C1C(C(C(O1)C2=NNC(=C2O)C(=O)N)O)O)O
Molecular Weight (in g/mol)259.218
TargetReplication
Assay TypeCPE reduction assay
Assay DescriptionCPE Assay
Assay Source
Cell TypeVero E6 cells
OutcomeInhibit replication
IC50 (in nM)
EC50 (in nM)
H-bond Acceptor8
H-bond Donor6
No. of Rotatable Bond Count3
XLogP-1.6
PSA161.92
Reference(s)https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1472238/
PubMed ID [Source Literature] 16641448
Curatorkanikatuteja@gmail.com