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Record - 1 of 4   [TOP]
Compound IDNVIC0003
Compound Structure
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InhibitorR1479
PubChem ID 457388
Drug Bank ID
ChemSpider ID 402579
SMILESC1=CN(C(=O)N=C1N)C2C(C(C(O2)(CO)N=[N+]=[N-])O)O
Molecular Weight284.232 g/mol
TargetRNA dependent RNA Polymerase
Assay TypeREPORTER ASSAYS
Assay DescriptionDose-response curve analysis
Assay Source Carbosynth US LLC, San Diego, CA, USA
Cell TypeNCI-H358 cells
OutcomeInhibition of transcription in NiV-Luc2AM
IC50 (in nM)
EC50 (in nM)1120
H-bond Acceptor7
H-bond Donor4
No. of Rotatable Bond Count3
XLogP-2.1
PSA140.97
Reference(s)Https://www.ncbi.nlm.nih.gov/pubmed/28629988
PubMed ID [Source Literature] 28629988
CuratorAnshu@imtech.res.in

                  
Record - 2 of 4   [TOP]
Compound IDNVIC0003
Compound Structure
DOWNLOAD:
InhibitorR1479
PubChem ID 457388
Drug Bank ID
ChemSpider ID 402579
SMILESC1=CN(C(=O)N=C1N)C2C(C(C(O2)(CO)N=[N+]=[N-])O)O
Molecular Weight284.232 g/mol
TargetRNA dependent RNA Polymerase
Assay TypeCytopathic effect assay(CPE)
Assay DescriptionHigh-throughput screening
Assay Source Carbosynth US LLC, San Diego, CA, USA
Cell TypeNCI-H358 cells
OutcomeChain termination, halt in replication
IC50 (in nM)
EC50 (in nM)2630
H-bond Acceptor7
H-bond Donor4
No. of Rotatable Bond Count3
XLogP-2.1
PSA140.97
Reference(s)Https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5648002/
PubMed ID [Source Literature] 28629988
CuratorKanikatuteja@gmail.com

                  
Record - 3 of 4   [TOP]
Compound IDNVIC0003
Compound Structure
DOWNLOAD:
InhibitorR1479
PubChem ID 457388
Drug Bank ID
ChemSpider ID 402579
SMILESC1=CN(C(=O)N=C1N)C2C(C(C(O2)(CO)N=[N+]=[N-])O)O
Molecular Weight284.232 g/mol
TargetRNA dependent RNA Polymerase
Assay TypeWT virus titer reduction
Assay DescriptionVisually inquired for CPE
Assay Source Carbosynth US LLC, San Diego, CA, USA
Cell TypeNCI-H358 cells
OutcomeChain termination, halt in replication
IC50 (in nM)
EC50 (in nM)1530
H-bond Acceptor7
H-bond Donor4
No. of Rotatable Bond Count3
XLogP-2.1
PSA140.97
Reference(s)Https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5648002/
PubMed ID [Source Literature] 28629988
CuratorKanikatuteja@gmail.com

                  
Record - 4 of 4   [TOP]
Compound IDNVIC0003
Compound Structure
DOWNLOAD:
InhibitorR1479
PubChem ID 457388
Drug Bank ID
ChemSpider ID 402579
SMILESC1=CN(C(=O)N=C1N)C2C(C(C(O2)(CO)N=[N+]=[N-])O)O
Molecular Weight284.232 g/mol
TargetRNA dependent RNA Polymerase
Assay TypeReporter assay
Assay DescriptionDose-response curve analysis
Assay Source Carbosynth US LLC, San Diego, CA, USA
Cell TypeNCI-H358 cells
OutcomeInhibition of transcription in NiV-GFP2AM
IC50 (in nM)
EC50 (in nM)1640
H-bond Acceptor7
H-bond Donor4
No. of Rotatable Bond Count3
XLogP-2.1
PSA140.97
Reference(s)Https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5648002/
PubMed ID [Source Literature] 28629988
CuratorPriyankapaul008@gmail.com