Lsit of proteins involved in saRNA phenomenon.
S. No. |
Protein Name |
Accession number | Gene Symbol |
Protein network |
|
Link |
Link |
|
dsRNA binding |
1 |
dsRNA-binding protein Staufen homolog 1 |
O95793 |
STAU1 |
 |
|  |
 |
2 |
Interleukin enhancer-binding factor 3 |
Q12906 | ILF3 |
 |
|  |
 |
3 |
Eukaryotic translation initiation factor 2C, 3 |
Q5TA56 | EIF2C3 |
 |
|  |
 |
4 |
Protein argonaute-2 |
Q9UKV8 | EIF2C2 |
 |
|  |
 |
|
Nucleic acids binding/ Splicing/ Chromatin/ Transcription |
5 |
Polyadenylate-binding protein 1 |
P11940 | PABPC1 |
 |
|  |
 |
6 |
Heterogeneous nuclear ribonucleoproteins A2/B1 |
P22626 | HNRNPA2B1 |
 |
|  |
 |
7 |
Heterogeneous nuclear ribonucleoprotein H |
P31943 | HNRNPH1 |
 |
|  |
 |
8 |
Heterogeneous nuclear ribonucleoprotein M |
P52272 | HNRNPM |
 |
|  |
 |
9 |
Poly(rC)-binding protein 2 |
Q15366 | PCBP2 |
 |
|  |
 |
10 |
Splicing factor, proline- and glutamine-rich |
P23246 | SFPQ |
 |
|  |
 |
11 |
RNA polymerase-associated protein CTR9 homolog |
Q6PD62 | CTR9 |
 |
|  |
 |
12 |
ATP-dependent RNA helicase A |
Q08211 | RHA |
 |
|  |
 |
13 |
H2AFA (Histone H2A type 1-B/E) |
P04908 | HIST1H2AB/E |
 |
|  |
 |
14 |
Polyubiquitin-B |
P0CG47 | UBB |
 |
|  |
 |
|
Translation |
15 |
Nucleophosmin |
P06748 | NPM1 |
 |
|  |
 |
16 |
Eukaryotic initiation factor 4A-I |
P60842 | EIF4A1 |
 |
|  |
 |
17 |
Elongation factor 1-alpha 1 |
P68104 | EEF1A1 |
 |
|  |
 |
|
Metabolic proteins |
18 |
Acetyl-CoA carboxylase 2 |
O00763 | ACACB |
 |
|  |
 |
19 |
Alpha-enolase |
P06733 | ENO1 |
 |
|  |
 |
20 |
Acetyl-CoA carboxylase 1 |
Q13085 | ACACA |
 |
|  |
 |
21 |
Fructose-bisphosphate aldolase A |
P04075 | ALDOA |
 |
|  |
 |
22 |
Pyruvate kinase isozymes M1/M2 |
P14618 | PKM |
 |
|  |
 |
23 |
Phosphoglycerate kinase 1 |
P00558 | PGK1 |
 |
|  |
 |
|
Chaperones |
24 |
Heat shock protein HSP 90-alpha |
P07900 | HSP90AA1 |
 |
|  |
 |
25 |
Heat shock 70 kDa protein 1A/1B |
P08107 | HSPA1A/B |
 |
|  |
 |
26 |
Heat shock cognate 71 kDa protein |
P11142 | HSPA8 |
 |
|  |
 |
|
Cytoskeleton proteins |
27 |
Putative annexin A2-like protein |
A6NMY6 | ANXA2P2 |
 |
|  |
 |
28 |
Annexin A2 |
P07355 | ANXA2 |
 |
|  |
 |
29 |
Tubulin beta-4 chain |
P04350 | TUBB4A |
 |
|  |
 |
30 |
Tubulin beta chain |
P07437 | TUBB |
 |
|  |
 |
31 |
Vinculin |
P18206 | VCL |
 |
|  |
 |
32 |
Actin, cytoplasmic 1 |
P60709 | ACTB |
 |
|  |
 |
33 |
Plectin |
Q15149 | PLEC |
 |
|  |
 |
34 |
Filaggrin-2 |
Q5D862 | FLG2 |
 |
|  |
 |
35 |
Filamin-A |
P21333 | FLNA |
 |
|  |
 |
36 |
Tubulin alpha-1B chain |
P68363 | TUBA1B |
 |
|  |
 |
|
Ribosomal proteins |
37 |
40S ribosomal protein SA |
P08865 | RPSA |
 |
|  |
 |
38 |
40S ribosomal protein S2 |
P15880 | RPS2 |
 |
|  |
 |
39 |
60S ribosomal protein L7 |
P18124 | RPL7 |
 |
|  |
 |
|
Miscellaneous |
40 |
Polymeric immunoglobulin receptor |
P01833 | PIGR |
 |
|  |
 |
41 |
OSBPL1A protein |
Q8IVZ3 | OSBPL1A |
 |
|  |
 |
42 |
Statherin |
P02808 | STATH |
 |
|  |
 |
References:
1) Demystifying the mechanistic and functional aspects of p21 gene activation with double-stranded RNAs in human cancer cells.
Wu HL, Li SM, Hu J, Yu X, Xu H, Chen Z, Ye ZQ.
J Exp Clin Cancer Res. 2016 Sep 17;35(1):145. doi: 10.1186/s13046-016-0423-y.
PMID: 27639690
2) saRNA-guided Ago2 targets the RITA complex to promoters to stimulate transcription.
Portnoy V, Lin SH, Li KH, Burlingame A, Hu ZH, Li H, Li LC.
Cell Res. 2016 Mar;26(3):320-35. doi: 10.1038/cr.2016.22. Epub 2016 Feb 23.
PMID: 26902284
3) Small activating RNA binds to the genomic target site in a seed-region-dependent manner.
Meng X, Jiang Q, Chang N, Wang X, Liu C, Xiong J, Cao H, Liang Z.
Nucleic Acids Res. 2016 Mar 18;44(5):2274-82. doi: 10.1093/nar/gkw076. Epub 2016 Feb 11.
PMID: 26873922
4) Promoter-associated small double-stranded RNA interacts with heterogeneous nuclear ribonucleoprotein A2/B1 to induce transcriptional activation.
Hu J, Chen Z, Xia D, Wu J, Xu H, Ye ZQ.
Biochem J. 2012 Nov 1;447(3):407-16. doi: 10.1042/BJ20120256.
PMID: 23035981