Lsit of proteins involved in saRNA phenomenon.


S. No. Protein Name Accession numberGene Symbol Protein network Link Link
dsRNA binding
1 dsRNA-binding protein Staufen homolog 1 O95793 STAU1
2 Interleukin enhancer-binding factor 3 Q12906ILF3
3 Eukaryotic translation initiation factor 2C, 3 Q5TA56 EIF2C3
4 Protein argonaute-2 Q9UKV8EIF2C2
  Nucleic acids binding/ Splicing/ Chromatin/ Transcription
5 Polyadenylate-binding protein 1 P11940PABPC1
6 Heterogeneous nuclear ribonucleoproteins A2/B1 P22626HNRNPA2B1
7 Heterogeneous nuclear ribonucleoprotein H P31943HNRNPH1
8 Heterogeneous nuclear ribonucleoprotein M P52272HNRNPM
9 Poly(rC)-binding protein 2 Q15366PCBP2
10 Splicing factor, proline- and glutamine-rich P23246SFPQ
11 RNA polymerase-associated protein CTR9 homolog Q6PD62CTR9
12 ATP-dependent RNA helicase A Q08211RHA
13 H2AFA (Histone H2A type 1-B/E) P04908HIST1H2AB/E
14 Polyubiquitin-B P0CG47UBB
  Translation
15 Nucleophosmin P06748NPM1
16 Eukaryotic initiation factor 4A-I P60842EIF4A1
17 Elongation factor 1-alpha 1 P68104EEF1A1
  Metabolic proteins
18 Acetyl-CoA carboxylase 2 O00763ACACB
19 Alpha-enolase P06733ENO1
20 Acetyl-CoA carboxylase 1 Q13085ACACA
21 Fructose-bisphosphate aldolase A P04075ALDOA
22 Pyruvate kinase isozymes M1/M2 P14618PKM
23 Phosphoglycerate kinase 1 P00558PGK1
  Chaperones
24 Heat shock protein HSP 90-alpha P07900HSP90AA1
25 Heat shock 70 kDa protein 1A/1B P08107HSPA1A/B
26 Heat shock cognate 71 kDa protein P11142HSPA8
  Cytoskeleton proteins
27 Putative annexin A2-like protein A6NMY6ANXA2P2
28 Annexin A2 P07355ANXA2
29 Tubulin beta-4 chain P04350TUBB4A
30 Tubulin beta chain P07437TUBB
31 Vinculin P18206VCL
32 Actin, cytoplasmic 1 P60709ACTB
33 Plectin Q15149PLEC
34 Filaggrin-2 Q5D862FLG2
35 Filamin-A P21333FLNA
36 Tubulin alpha-1B chain P68363TUBA1B
  Ribosomal proteins
37 40S ribosomal protein SA P08865RPSA
38 40S ribosomal protein S2 P15880RPS2
39 60S ribosomal protein L7 P18124RPL7
  Miscellaneous
40 Polymeric immunoglobulin receptor P01833PIGR
41 OSBPL1A protein Q8IVZ3OSBPL1A
42 Statherin P02808STATH


References:

1) Demystifying the mechanistic and functional aspects of p21 gene activation with double-stranded RNAs in human cancer cells.

Wu HL, Li SM, Hu J, Yu X, Xu H, Chen Z, Ye ZQ.

J Exp Clin Cancer Res. 2016 Sep 17;35(1):145. doi: 10.1186/s13046-016-0423-y.

PMID: 27639690

2) saRNA-guided Ago2 targets the RITA complex to promoters to stimulate transcription.

Portnoy V, Lin SH, Li KH, Burlingame A, Hu ZH, Li H, Li LC.

Cell Res. 2016 Mar;26(3):320-35. doi: 10.1038/cr.2016.22. Epub 2016 Feb 23.

PMID: 26902284

3) Small activating RNA binds to the genomic target site in a seed-region-dependent manner.

Meng X, Jiang Q, Chang N, Wang X, Liu C, Xiong J, Cao H, Liang Z.

Nucleic Acids Res. 2016 Mar 18;44(5):2274-82. doi: 10.1093/nar/gkw076. Epub 2016 Feb 11.

PMID: 26873922

4) Promoter-associated small double-stranded RNA interacts with heterogeneous nuclear ribonucleoprotein A2/B1 to induce transcriptional activation.

Hu J, Chen Z, Xia D, Wu J, Xu H, Ye ZQ.

Biochem J. 2012 Nov 1;447(3):407-16. doi: 10.1042/BJ20120256.

PMID: 23035981

saRNA - small activating RNA