Chemical Information
Antiviral agent ID	DrugRepV_7976
Antiviral agent name	Suramin
IUPAC Name	8-[[4-methyl-3-[[3-[[3-[[2-methyl-5-[(4,6,8-trisulfonaphthalen-1-yl)carbamoyl]phenyl]carbamoyl]phenyl]carbamoylamino]benzoyl]amino]benzoyl]amino]naphthalene-1,3,5-trisulfonic acid
SMILES (canonical)	CC1=C(C=C(C=C1)C(=O)NC2=C3C(=CC(=CC3=C(C=C2)S(=O)(=O)O)S(=O)(=O)O)S(=O)(=O)O)NC(=O)C4=CC(=CC=C4)NC(=O)NC5=CC=CC(=C5)C(=O)NC6=C(C=CC(=C6)C(=O)NC7=C8C(=CC(=CC8=C(C=C7)S(=O)(=O)O)S(=O)(=O)O)S(=O)(=O)O)C
Molecular Formula	C51H40N6O23S6
Molecular Weight (g/mol)	1297.26
InChl	InChI=1S/C51H40N6O23S6/c1-25-9-11-29(49(60)54-37-13-15-41(83(69,70)71)35-21-33(81(63,64)65)23-43(45(35)37)85(75,76)77)19-39(25)56-47(58)27-5-3-7-31(17-27)52-51(62)53-32-8-4-6-28(18-32)48(59)57-40-20-30(12-10-26(40)2)50(61)55-38-14-16-42(84(72,73)74)36-22-34(82(66,67)68)24-44(46(36)38)86(78,79)80/h3-24H,1-2H3,(H,54,60)(H,55,61)(H,56,58)(H,57,59)(H2,52,53,62)(H,63,64,65)(H,66,67,68)(H,69,70,71)(H,72,73,74)(H,75,76,77)(H,78,79,80)
Common Name	Suramin
Synonyms	8,8'-[CARBONYLBIS[imino-3,1-phenylenecarbonylimino(4-methyl-3,1-phenylene)carbonylimino]]bis-1,3,5-naphthalenetrisulfonic acid | Belganyl | Naganol | Naphuride | Suramin | Suramine
Structural Information
Clinical Information
Category	Antiparasitic products, Insectisides and Repellents
Primary Indication (Clinical trial phases)	Investigational
Biological Information
Primary Indication (Disease Category)	Non Infectious Disease | Infectious Disease
Primary Indication (Disease)	Sleeping sickness | Onchocerciasis
Primary Indication (Drug target/Mode of Action)	Plexin-A1
Secondary Indication	Chikungunya virus (CHIKV) NA S2.1
Secondary Indication (Approaches)	Experimental
Secondary Indication (Methods)	In-vitro
Secondary Indication (Model system) [cell lines/ animal models]	VeroE6 cells
Secondary Indication (Viral titer)	0.05 MOI
Secondary Indication (Mode of drug delivery)	Culture
Secondary Indication (Drug concentration)	91 ± 20 μM
Secondary Indication (Cell based assay)	CPE reduction assay
Secondary Indication (Change)	Decrease
Secondary Indication (Type of Inhibition)	EC50 [ 50 % ]
Reference	Albulescu IC, White-Scholten L, Tas A, Hoornweg TE, Ferla S, Kovacikova K, Smit JM, Brancale A, Snijder EJ, van Hemert MJ..Suramin Inhibits Chikungunya Virus Replication by Interacting with Virions and Blocking the Early Steps of Infection..Viruses. 2020 Mar 17;12(3):314. doi: 10.3390/v12030314. PMCID: PMC7150963. PMID:32191995
Comment	Suramin interferes with CHIKV entry by interacting with the E2 envelope protein, which inhibits attachment and also interferes with conformational changes required for fusion.